| 细胞核增殖抗原ki-67在异位和在位子宫内膜中的表达 |
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| 引用本文： | 柯妍,沙青,严丽.细胞核增殖抗原ki-67在异位和在位子宫内膜中的表达[J].中国妇幼保健,2011,26(29):4603-4605. |
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| 作者姓名： | 柯妍 沙青 严丽 |
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| 作者单位： | 新疆乌鲁木齐市妇幼保健院妇科 830001 |
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| 摘 要： | 目的:探讨细胞核增殖抗原ki-67在子宫内膜异位症中的表达和子宫内膜细胞增殖能力对子宫内膜异位症发病的影响。方法:应用免疫组化SP法检测58例子宫内膜异位症(EMS组)患者(包括36例卵巢子宫内膜异位症和22例子宫腺肌症)的异位内膜和在位内膜及15例子宫肌瘤患者子宫内膜(对照组)中ki-67的表达情况,以增殖指数为统计指标。结果:卵巢EMS和子宫腺肌症的在位和异位内膜ki-67的表达差异均无统计学意义;对照组子宫内膜和EMS组在位内膜的腺体和间质的ki-67表达在增生期均显著高于分泌期,EMS异位内膜增殖指数在增生期和分泌期差异无统计学意义(P>0.05);EMS异位内膜ki-67增殖指数在增殖期低于在位内膜,但在分泌期则显著高于在位内膜(P<0.01);EMS异位内膜腺体Ⅰ～Ⅱ期时的ki-67表达高于Ⅲ、Ⅳ期(P<0.05),但在位内膜的ki-67表达在不同临床分期中差异无统计学意义(P>0.05)。结论:ki-67增殖指数反映了子宫内膜细胞的增殖活性,EMS异位内膜细胞持续增殖活跃可能在子宫内膜异位症发生、发展中起重要作用。
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| 关 键 词： | 子宫内膜异位症 ki-67 免疫组化 在位内膜 异位内膜 |
Expression of proliferation cell nuclear antigen ki -67 in ectopic endometrium and eutopic endometrium |
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| KE Yan,SHA Qing,YAN Li.Expression of proliferation cell nuclear antigen ki -67 in ectopic endometrium and eutopic endometrium[J].Maternal and Child Health Care of China,2011,26(29):4603-4605. |
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| Authors: | KE Yan SHA Qing YAN Li |
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| Institution: | KE Yan,SHA Qing,YAN Li.Department of Gynecology,Urumqi Maternal and Child Health Hospital,Urumqi 830001,Xinjiang,China |
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| Abstract: | Objective:To explore the expression of proliferation cell nuclear antigen ki-67 in endometriosis and the effect of proliferative activity of endometrial cells on the occurrence of endometriosis.Methods:Immunohistochemical SP method was used to detect the expression levels of ki-67 in ectopic endometrium and eutopic endometrium of 58 cases with endometriosis(endometriosis group,including 36 cases with ovarian endometriosis and 22 cases with adenomyosis) and normal endometrium of 15 cases with hysteromyoma(co... |
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| Keywords: | Endometriosis ki-67 Immunohistochemistry Eutopic endometrium Ectopic endometrium |
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