香莪胶囊治疗子宫内膜异位症的临床疗效观察

目的:观察香莪胶囊治疗子宫内膜异位症的临床疗效及安全性。方法:选择经腹腔镜或开腹手术确诊Ⅲ～Ⅳ期子宫内膜异位症患者63例,随机分为香莪胶囊组31例,采用口服香莪胶囊,每次3粒,每天3次,每天6 g;达那唑组32例,每次口服达那唑200 mg,每日3次,共600 mg,两组治疗疗程共12周。分别于治疗前后测定两组患者的疼痛症状评分(NRS)、外周血及经血中雌二醇(E2)水平及外周血白细胞介素-8含量,患者治疗结束后进行NRS评分。结果:①两组患者临床疗效比较:香莪胶囊组31例,临床痊愈12例(38.71%),显效8例(25.81%),有效6例(19.35%),无效5例(16.12%),有效率83.87%;达那唑组32例,临床痊愈11例(34.37%),显效8例(25.00%),有效7例(21.88%),无效6例(18.75%),总有效率81.25%;两组临床疗效比较无统计学差异(P>0.05)。②两组患者治疗前后血清及经血中E2和IL-8水平比较:两组患者治疗前血清和经血中E2水平比较差异均无统计学意义(P>0.05);治疗3月后,两组患者血清E2水平无明显变化,而经血中E2水平逐渐降低,与治疗前比较差异有统计学意义(P<0.01),但两组经血中E2降低水平比较,差异无统计学意义(P>0.05);香莪胶囊组血清和经血中IL-8水平明显降低,而达那唑组无变化,两组比较差异有统计学意义(P<0.01)。结论:香莪胶囊对子宫内膜异位症有良好的治疗作用,其机制可能与降低血清及经血中IL-8水平有关。

Observation on the clinical curative effect of Xiang'e capsule in treatment of endometriosis

Objective:To observe the clinical efficacy and safety of Xiang'e capsule in treatment of endometriosis.Methods:63 patients with stage Ⅲ～Ⅳ endometriosis diagnosed definitely by laparoscopy or laparotomy were randomly divided into Xiang'e capsule group(31 patients) and danazol group(32 patients).The patients in Xiang'e capsule group were treated with oral administration of Xiang'e capsule,three capsules once,three times a day,6 g every day;while the patients in danazol group were treated with oral administration of danazol,200 mg per time,three times a day,600 mg one day;the courses of treatment in the two groups both were 12 weeks.Numeric rating scale(NRS),the levels of estradiol in peripheral blood and menstrual blood,interleukin-8 content in peripheral blood were detected before and after treatment,after treatment,NRS scoring was performed.Results:①Comparison of clinical efficacy between the two groups: among 31 patients in Xiang'e capsule group,12 patients(38.71%) were cured,8 cases(25.81%) were obvious effective,6 patients(19.35%) were effective,5 patients(16.12%) were non-effective,the total effective rate was 83.87%.Among 32 patients in danazol group,11 patients(34.37%) were cured,8 patients(25.00%) were obvious effective,7 patients(21.88%) were effective,6 patients(18.75%) were non-effective,the total effective rate was 81.25%;there was no significant difference in the total effective rate between the two groups(P>0.05).②Comparison of levels of estradiol in peripheral blood and menstrual blood,interleukin-8 content in peripheral blood between the two groups: before treatment,there was no significant difference in the levels of estradiol in peripheral blood and menstrual blood between the two groups(P>0.05).At three months after treatment,serum estradiol levels in the two groups didn't change significantly,but the estradiol level in menstrual blood decreased gradually,compared with before treatment,there was significant difference(P<0.01).There was no significant difference in the decrease level of estradiol in menstrual blood between the two groups(P>0.05).The levels of interleukin-8 in peripheral blood and menstrual blood of Xiang'e capsule group deceased significantly,while the levels of interleukin-8 in peripheral blood and menstrual blood of danazol group didn't change,there was significant difference between the two groups(P<0.01).Conclusion:The curative effect of Xiang'e capsule is good for cases with endometriosis,the mechanism may be related to the decreases of interleukin-8 in peripheral blood and menstrual blood.