| COX-2、HPV16-E6蛋白在宫颈癌组织中的表达及临床意义 |
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| 引用本文： | 张莉华,田芬,辛华栋. COX-2、HPV16-E6蛋白在宫颈癌组织中的表达及临床意义[J]. 中国妇幼保健, 2011, 26(32): 5062-5066 |
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| 作者姓名： | 张莉华 田芬 辛华栋 |
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| 作者单位： | 河北省邯郸市中心医院妇二科 056001 |
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| 摘 要： | 目的:探讨环氧合酶-2(cyclooxygenase-2,COX-2)和人乳头瘤病毒16型E6蛋白(human papillomavirus-16 E6 protein,HPV16-E6)在宫颈癌中的表达及其与临床病理特征之间的关系。方法:采用免疫组化S-P法检测COX-2和HPV16-E6蛋白在宫颈癌上皮中的阳性表达情况。结果:COX-2与淋巴结转移、宫旁或脉管浸润及肌层浸润深度呈显著性相关(P<0.05)。HPV16-E6与年龄、病理类型、宫旁或脉管浸润呈显著性相关(P<0.05)。COX-2和HPV16-E6蛋白在宫颈癌中的阳性率呈正相关(P<0.01)。结论:COX-2和HPV16-E6在宫颈癌的侵袭转移中可能发挥协同作用。联合应用选择性COX-2抑制剂和HPV疫苗是宫颈癌防治中的一个新的有效策略。
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| 关 键 词： | 宫颈癌 环氧合酶-2 人乳头瘤病毒16型E6蛋白 免疫组化 |
The expression and clinical significance of COX -2 and HPV16 -E6 in cervical cancer |
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| ZHANG Li-Hua,TIAN Fen,XIN Hua-Dong. The expression and clinical significance of COX -2 and HPV16 -E6 in cervical cancer[J]. Maternal and Child Health Care of China, 2011, 26(32): 5062-5066 |
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| Authors: | ZHANG Li-Hua TIAN Fen XIN Hua-Dong |
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| Affiliation: | ZHANG Li-Hua,TIAN Fen,XIN Hua-Dong.The department gynecologic,Center Hospital of Handan,Handan 056001,Hebei,China |
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| Abstract: | Objective:To investigate the expression of COX-2 and HPV16-E6 in the occurrence and development of cervical cancer.Methods:The expression of COX-2 and HPV16-E6 protein was examined with immunohistochemistry.Results:The positive expression of COX-2 was associated with lymph node metastasis,infiltration of latero-uterus or haemal tube and infiltrative depth of muscle(P<0.05).The positive expression of HPV16-E6 was associated with the age of the patients,pathological types and the infiltration of latero-uterus... |
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| Keywords: | Cervical cancer COX-2 HPV16-E6 Immunohistochemistry |
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