| 壳聚糖和PHBHHx用作神经修复导管材料的研究 |
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| 引用本文： | 杨吟野,李训虎,李国富,赵南明,张秀芳. 壳聚糖和PHBHHx用作神经修复导管材料的研究[J]. 生物医学工程学杂志, 2002, 19(1): 25-29 |
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| 作者姓名： | 杨吟野 李训虎 李国富 赵南明 张秀芳 |
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| 作者单位： | 1. 清华大学,生物科学与技术系,生物膜与膜生物工程国家重点实验室,北京,100084;贵州民族学院,物理系,贵阳,550025
2. 清华大学,生物科学与技术系,生物膜与膜生物工程国家重点实验室,北京,100084 |
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| 基金项目： | 海洋“8 6 3”项目资助 ( 819-0 7-0 1) |
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| 摘 要： | 壳聚糖(Chitosan)和PHBHHx（羟基丁酸酯和羟基己酸酯共聚物）都是天然可降解材料。我们通过对这两种材料的亲水性、保持吸附蛋白有序结构的能力、胎鼠大脑皮层细胞在材料上生长情况以及两种材料的机械性能和后处理可加工性的研究，综合评价了它们作为神经修复导管材料的可行性。指出它们都有希望作为神经修复导管的材料。
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| 关 键 词： | 壳聚糖 PHBHHx 神经导管 神经再生 神经细胞 蛋白吸附 |
Study on Chitosan and PHBHHx Used as Nerve Regeneration Conduit Material |
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| Yinye Yang,Xunhu Li,Guofu Li,Nanming Zhao,Xiufang Zhang. Study on Chitosan and PHBHHx Used as Nerve Regeneration Conduit Material[J]. Journal of biomedical engineering, 2002, 19(1): 25-29 |
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| Authors: | Yinye Yang Xunhu Li Guofu Li Nanming Zhao Xiufang Zhang |
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| Affiliation: | Department of Biological Sciences and Biotechnology, State Key Laboratory of Biomembrane and Membrane Biotechnology, Tsinghua University, Beijing 100084. |
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| Abstract: | Both Chitosan and PHBHHx are natural, biodegradable biomedical materials. In this article, their ability to be made as nerve regeneration conduits are evaluated by studying their wettability, changes of the second structure of protein absorbed on their surface, growing status of fetal rat cerebral cortex nerve cells cultured on them, mechanical properties and ability to be processed later. The results indicate that both Chitosan and PHBHHx are promising nerve conduit materials. |
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| Keywords: | Chitosan PHBHHx Nerve conduits Nerve regeneration Nerve cells Protein adsorption |
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