| 加味七方胃痛颗粒对慢性萎缩性胃炎大鼠胃蛋白酶含量及HSP70蛋白表达的影响 |
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| 引用本文： | 唐梅文,王伟,李桂贤,岳小红,陈国忠,邓嫦.加味七方胃痛颗粒对慢性萎缩性胃炎大鼠胃蛋白酶含量及HSP70蛋白表达的影响[J].中药新药与临床药理,2011,22(1). |
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| 作者姓名： | 唐梅文 王伟 李桂贤 岳小红 陈国忠 邓嫦 |
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| 作者单位： | 1. 广西中医学院,南宁,530001
2. 广西中医学院第一附属医院,南宁,530023 |
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| 摘 要： | 目的 探讨加味七方胃痛颗粒对慢性萎缩性胃炎(CAC)模型大鼠胃黏膜组织中胃蛋白酶含量及热休克蛋白70(HSP70)表达的影响.方法 采用化学致癌物N-甲基-N'-硝基-N-亚硝基胍(MNNG)建立CAG动物模型,以胃复春为对照组,观察加味七方胃痛颗粒对大鼠CAG相关指标的作用.结果 与模型组比较,加味七方胃痛颗粒高、中剂量组和胃复春组的胃黏膜萎缩程度、胃黏膜肠化生程度明显减轻(P＜0.01);加味七方胃痛颗粒高、中、低剂量组和胃复春组胃蛋白酶的含量、HSP70蛋白表达显著增加(P＜0.01);与胃复春组比较,加味七方胃痛颗粒高剂量组胃蛋白酶的含量、HSP70蛋白表达显著增加(P＜0.05).结论 加味七方胃痛颗粒防治CAG的作用机制可能是通过升高胃蛋白酶的含量及促进HSP70的表达,从而发挥对黏膜保护作用.
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| 关 键 词： | 慢性萎缩性胃炎 加味七方胃痛颗粒 胃蛋白酶 热休克蛋白70 |
Effect of Modified Qifang Weitong Granules on Pepsin Content and Heat Shock Protein 70 Expression in Rats with Chronic Atrophic Gastritis |
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| TANG Meiwen,WANG Wei,LI Guixian,YUE Xiaohong,CHEN Guozhong,DENG Chang.Effect of Modified Qifang Weitong Granules on Pepsin Content and Heat Shock Protein 70 Expression in Rats with Chronic Atrophic Gastritis[J].Traditional Chinese Drug Research & Clinical Pharmacology,2011,22(1). |
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| Authors: | TANG Meiwen WANG Wei LI Guixian YUE Xiaohong CHEN Guozhong DENG Chang |
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| Institution: | TANG Meiwen1,WANG Wei2,LI Guixian3,YUE Xiaohong2,CHEN Guozhong3,DENG Chang3(1.Guangxi College of TCM,Nanning 530001,China,2.Graduate Student in 2007,Guangxi College of TCM,3.The First Affiliated Hospital of Guangxi College of TCM,China) |
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| Abstract: | Objective To investigate the effects of Modified Qifan Weitong Granules(QWG)on pepsin content and heat shock protein 70(HSP70)expression in the gastric mucosa of rats with chronic atrophic gastritis(CAG). Methods CAG rat models were established by means of N-methyl-N's-nitro-N-nitrosoguanidine(MNNG),and the effect of QWG on relative indexes was observed and compared with that of Weifuchun Granules.Results Compared with the model group,the atrophy and intestinal metaplasia of gastric mucosa were relieved in ... |
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| Keywords: | Chronic atrophic gastritis Modified Qifan Weitong Granules Pepsin HSP70 |
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