| 参莲提取物抗炎药理活性评价 |
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| 引用本文： | 李玉洁,杨庆,翁小刚,陈颖,朱晓新. 参莲提取物抗炎药理活性评价[J]. 中药新药与临床药理, 2011, 22(1) |
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| 作者姓名： | 李玉洁 杨庆 翁小刚 陈颖 朱晓新 |
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| 作者单位： | 中国中医科学院中药研究所,北京,100700 |
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| 基金项目： | 国家直属科研院所技术开发研究专项资金，国家自然科学基金面上项目，重大新药创制综合性中药新药研究开发技术大平台项目，中国中医科学院自主选题项目 |
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| 摘 要： | 目的 评价参莲提取物的抗炎作用.方法 采用巴豆油诱导小鼠急性耳肿胀模型、大鼠慢性肉芽肿模型、脂多糖(lipopolysaccharide,LPS)诱导小鼠急性肺炎性损伤模型、家兔内皮剥脱复合高脂诱导动脉粥样硬化(atherosclerosis,AS)早期炎症损伤模型等,对中药复方制剂参莲提取物进行抗炎药理作用评价.结果 参莲提取物可抑制大鼠肉芽肿生成,降低家兔AS早期炎症反应,对小鼠急性肺炎症损伤反应有一定的抑制作用,对巴豆油诱导小鼠急性耳肿胀无明显治疗作用.结论 参莲提取物具有明显的抗炎作用,对慢性、亚急性炎症的治疗作用优于急性炎症.
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| 关 键 词： | 参莲提取物 抗炎 疾病动物模型 |
Evaluation of Anti-inflammatory Effects of Shenlian Extracts |
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| LI Yujie,YANG Qing,WENG Xiaogang,CHEN Ying,ZHU Xiaoxin. Evaluation of Anti-inflammatory Effects of Shenlian Extracts[J]. Traditional Chinese Drug Research & Clinical Pharmacology, 2011, 22(1) |
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| Authors: | LI Yujie YANG Qing WENG Xiaogang CHEN Ying ZHU Xiaoxin |
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| Affiliation: | LI Yujie,YANG Qing,WENG Xiaogang,CHEN Ying,ZHU Xiaoxin(Institute of Chinese Materia Medica,China Academy of Chinese Medical sciences,Beijing 100700,China) |
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| Abstract: | Objective To assess the anti-inflammatory activity of extracts from Shenlian(mainly composed of Radix Sophorae Flavescentis,Radix Sophorae Tonkinensis,Herba Scutellariae Barbatae,etc.).Methods The anti-inflammatory effects of Shenlian extracts were studied on mice model of croton oil-induced acute auricular swelling,rats model of chronic granuloma,mice model of lipopolysaccharide-induced acute lung pneumonia,and rabbits model of subacute stage vascular inflammatory injury in atherosclerosis induced by endot... |
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| Keywords: | Shenlian extracts Anti-inflammation Animal models of diseases |
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