| 柳州市新生儿乙肝疫苗免疫效果观察 |
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| 引用本文： | 吴昕,王晓伟,崔雪莲.柳州市新生儿乙肝疫苗免疫效果观察[J].职业与健康,2011,27(1):52-53. |
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| 作者姓名： | 吴昕 王晓伟 崔雪莲 |
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| 作者单位： | 广西壮族自治区柳州市疾病预防控制中心免疫规划科,545007 |
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| 基金项目： | 广西科技厅项目，广西卫生厅项目，柳州市科技局项目 |
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| 摘 要： | 目的观察新生儿接种乙型肝炎(乙肝)疫苗后的免疫效果,分析新生儿乙肝疫苗低(无)应答的可能原因,探讨提高乙肝疫苗免疫应答率的可行方案。方法采用单纯随机抽样方法从柳州市城区选取812名按规定免疫程序全程接种3针乙肝疫苗的1岁内儿童为研究对象。采集血样标本并进行问卷调查。采用化学发光微粒子免疫分析法(CM IA)定量检测抗-HBs;抗-HBs<100 U/L者采用ELISA方法(国产试剂)检测HBsAg。结果 812名观察对象中,免疫失败2人(0.25%),低(无)应答者70人(8.62%),正常应答者740人(91.13%);正常免疫应答率只与产程有关,与性别、出生体重、民族等无关。结论新生儿按规定程序接种乙肝疫苗后仍有近10%为低(无)应答者,开展抗-HBs检测,找出低(无)应答者并进行再免,对降低我国乙肝病毒携带率是非常必要的。
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| 关 键 词： | 乙肝疫苗 乙肝表面抗体 免疫效果 |
Observation on Immunogenicity of Hepatitis B Vaccine on Neonate in Liuzhou City |
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| WU Xin,WANG Xiao-wie,CHUI Xie-lian.Observation on Immunogenicity of Hepatitis B Vaccine on Neonate in Liuzhou City[J].Occupation and Health,2011,27(1):52-53. |
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| Authors: | WU Xin WANG Xiao-wie CHUI Xie-lian |
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| Institution: | WU Xin,WANG Xiao-wei,CUI Xue-lian(Liuzhou Center for Disease Control and Prevention,Guangxi,545007,China) |
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| Abstract: | Objective]To observe the immune effect of hepatitis B vaccine on neonate,to analyze the possible reasons for low(no) immune response after inoculation of hepatitis b vaccine,and explore the feasible plan for improving immune response of hepatitis B vaccine.Methods]Simple random sampling method was adopted to select 812 infants within 1 year old inoculated hepatitis B vaccine with all 3 doses according immunization program as study objects.Their serum samples were collected and they were surveyed with ques... |
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| Keywords: | Hepatitis B vaccine HbsAb Immune effect |
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