| 石榴皮醇提物降血脂作用的实验研究 |
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| 引用本文： | 丁玮,孙建新,扎文峰,吕晓敏. 石榴皮醇提物降血脂作用的实验研究[J]. 中药新药与临床药理, 2011, 22(1) |
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| 作者姓名： | 丁玮 孙建新 扎文峰 吕晓敏 |
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| 作者单位： | 1. 新疆医科大学第一附属医院药剂科,乌鲁木齐,830011
2. 新疆医科大学医学实验动物中心,乌鲁木齐,830011 |
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| 摘 要： | 目的 观察石榴皮醇提物对高脂血症模型大鼠的降血脂作用.方法 将70只SD大鼠随机分为正常对照组、模型组、石榴皮醇提物低、中、高剂量组(400、800、1600 mg/kg)、阳性对照组.正常对照组和模型组给予等体积生理盐水,各给药组给予相应剂量的药物.连续给药4周后麻醉处死动物,测定各组大鼠血清甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、超氧化物歧化酶(SOD)、丙二醛(MDA)、肿瘤坏死因子(TNF-α)的含量.结果 与正常对照组比较,模型组TC、TG、LDL-C、MDA、TNF-α明显升高(P＜0.05),HDL-C、SOD明显下降(P＜0.05);与模型组比较,石榴皮醇提物高剂量组、中剂量组、阳性对照组TC、TG、LDL-C、MDA、TNF-α明显降低(P＜0.05),HDL-C、SOD明显升高(P<0.05);石榴皮醇提物中、高剂量组TC、TG、LDL-C、HDL-C、MDA与阳性对照组比较无显著性差异(P>0.05),而SOD、TNF-α与阳性对照组比较有显著性差异(P＜0.05).结论 石榴皮醇提物有较好的降血脂作用,其降脂机制可能是通过提高抗氧化作用、减少脂质过氧化产物实现的.
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| 关 键 词： | 石榴皮醇提物 大鼠 降血脂 胆固醇 |
Experimental Study on the Antihyperlipidemia Effect of Ethanol Extracts from Pericarpium Granati |
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| DING Wei,SUN Jianxin,ZHA Wenfeng,LV Xiaomin. Experimental Study on the Antihyperlipidemia Effect of Ethanol Extracts from Pericarpium Granati[J]. Traditional Chinese Drug Research & Clinical Pharmacology, 2011, 22(1) |
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| Authors: | DING Wei SUN Jianxin ZHA Wenfeng LV Xiaomin |
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| Affiliation: | DING Wei1,SUN Jianxin2,ZHA Wenfeng2,LV Xiaomin2(1.Department of Pharmacy,the First Affiliated Hospital of Xinjiang Medical University,Urumqi 830011,China,2.The Medical Laboratory Animal Center of Xinjiang Medical University,China) |
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| Abstract: | Objective To observe the lipid-lowering effect of ethanol extracts from Pericarpium Granati(EEPG).Methods Seventy SD rats were randomly divided into control group,model group,low-dose EEPG group(400 mg/kg),middle-dose EEPG group(800 mg/kg),high-dose EEPG group(1600 mg/kg),and positive control group.The medication groups were given corresponding drugs according to the experimental design,and the normal control group and the model group was administered with the same volume of physical saline.After treatment ... |
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| Keywords: | Ethanol Extracts from Pericarpium Granati Rats Lipid-lowering effect Cholesterol |
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