| 水蛭超细粉及水煎液活血化瘀作用的比较研究 |
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| 引用本文： | 祝晓雯,宋嬿,金若敏,宋哲平. 水蛭超细粉及水煎液活血化瘀作用的比较研究[J]. 中药新药与临床药理, 2011, 22(1) |
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| 作者姓名： | 祝晓雯 宋嬿 金若敏 宋哲平 |
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| 作者单位： | 1. 上海中医药大学中药新药药理毒理研究中心,上海,201203
2. 上海华宇药业有限公司,上海,200002 |
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| 摘 要： | 目的 比较水蛭超细粉与水煎液的活血化瘀作用强度.方法 采用小鼠出血时间测定法、大鼠冰水-肾上腺素血瘀模型,比较水蛭超细粉、水煎液口服给药后的作用强度;采用急性毒性试验对其安全性进行初步比较考察.结果 与正常对照组比较,超细粉高、低剂量(0.9 g生药/kg、0.45 g生药/kg)及水煎液高剂量(0.9 g生药/kg)可明显延长小鼠出血时间(P＜0.05或P＜0.01);与模型组比较,超细粉高、低剂量及水煎液高剂量(O.6g生药/kg)可明显缩短血栓长度(P＜0.05或P＜0.01),超细粉与水煎液高剂量(0.6 g生药/kg)均能减轻血栓的重量(P＜0.05),超细粉高剂量组(0.6 g生药/kg)FIB含量显著减少(P＜0.05);小鼠口服水蛭超细粉MTD为19.2 g生药/kg,水蛭水煎液LD50为19.9 g生药/kg.结论 水蛭经超细粉碎后,在延长小鼠出血时间、抑制模型大鼠静脉血栓形成,减轻静脉血栓重量等活血化瘀方面作用稍好于传统水煎液,在活血化瘀方面,细粉可替代水煎液,且携带方便.毒性相对减小.
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| 关 键 词： | 水蛭 血瘀 |
Comparative Study of Leech Ultrafine Powder and Decoction on Promoting Blood Circulation and Removing Blood Stasis |
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| ZHU Xiaowen,SONG Yan,JIN Ruomin,SONG Zheping. Comparative Study of Leech Ultrafine Powder and Decoction on Promoting Blood Circulation and Removing Blood Stasis[J]. Traditional Chinese Drug Research & Clinical Pharmacology, 2011, 22(1) |
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| Authors: | ZHU Xiaowen SONG Yan JIN Ruomin SONG Zheping |
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| Affiliation: | ZHU Xiaowen1,SONG Yan2,JIN Ruomin1,SONG Zheping1(1.Center for Pharmacology and Toxicology of Chinese Herbal Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China,2.Shanghai Huayu Pharmaceutical Co.,Ltd.,Shanghai 200002,China) |
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| Abstract: | Objective To compare the potency of leech ultrafine powder and decoction on promoting blood circulation and removing blood stasis.Methods A rat model of blood stasis was established by adrenaline injection and ice cold bath.After oral administration,the potency of leech ultrafine powder and decoction on promoting blood circulation and removing blood stasis were determined and compared.The acute toxicity test was carried out to evaluate and compare the safety of leech ultrafine powder and decoction.Results C... |
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| Keywords: | LD50 MTD |
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