| 心房Ca~(2+)稳态与心房颤动的发生机制 |
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| 引用本文： | 刘干. 心房Ca~(2+)稳态与心房颤动的发生机制[J]. 医学综述, 2011, 17(4): 484-486 |
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| 作者姓名： | 刘干 |
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| 作者单位： | 重庆医科大学附属第二医院心内科,重庆,400010 |
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| 摘 要： | 心肌细胞内Ca2+稳态异常是心房颤动发生的重要因素。FK506结合蛋白12.6调控RyR2的异常导致Ca2+漏出,受磷蛋白表达过高时对肌质网钙摄取通道Ca2+ATP酶的过度调控以及心房细胞L型钙电流的下调都是导致心房Ca2+稳态异常的机制,心房钙调控的一些关键部位则可能成为房颤治疗的靶点。心房内Ca2+稳态受钙释放通道、SERCA2a、L型钙通道等的调控,现就目前房颤发生机制的分子机制予以综述。
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| 关 键 词： | 心房颤动 钙稳态 分子机制 |
Atrial Ca2+ Homeostasis in the Mechanism of Atrial Fibrillation |
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| LIU Gan. Atrial Ca2+ Homeostasis in the Mechanism of Atrial Fibrillation[J]. Medical Recapitulate, 2011, 17(4): 484-486 |
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| Authors: | LIU Gan |
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| Affiliation: | LIU Gan,CHEN Yun-qing.(Department of Cardiology,the Second Affiliated Hospital of Chongqing Medical University,Chongqing 400010,China) |
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| Abstract: | The disrupted cardiomyocytic Ca2+ homeostasis is a major cause of atrial fibrillation.The dysregulation of RyR2 by FK506 binding protein 12.6 leads to the leakage of Ca2+.The overexpression of phospholamban that causes the overregulation of sarcoplasmic calcium uptake channel Ca2+-ATPase and the downregulation of atrial cardiomyocytic L-type calcium current are thought to be the mechanisms of disrupted atrial Ca2+ homeostasis.Some key links of atrial calcium regulation may be potential therapeutic targets f... |
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| Keywords: | Atrial fibrillation Ca2 homeostasis Molecular mechanisms |
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