125Ⅰ放射性粒子植入治疗骨转移瘤的临床观察

目的 总结125Ⅰ粒子植入治疗骨转移瘤的临床疗效.方法 对25例患者的32个不同来源的骨转移病灶行125Ⅰ粒子植入治疗,观察骨痛缓解情况以及术后骨转移病灶的影像学改变.结果 125Ⅰ粒子植入治疗骨转移瘤的止痛有效率为92 %,其中15例为显效,8例为有效,2例无效.治疗后疼痛分级明显降低（P＜0.05）.术后2个月影像学检查显示,病灶部分缓解者9个,稳定者16个,进展者7个,所有患者治疗后均未出现严重不良反应.结论 125Ⅰ粒子植入治疗骨转移瘤止痛疗效确切,不良反应少,是一种值得推广的治疗方法.

Clinical application of permanent implantation of iodine 125 seeds for osseous metastases

Objective To evaluate the clinical efficacy of permanent implantation of iodine 125 seeds in the treatment of osseous metastases. Methods Radioactive iodine 125 seeds were implanted permanently in 32 lesions of 25 patients with osseous metastases of different origins. The ostalgia-relieving degree and the imaging alterations of the osseous metastasis le- sions were observed. Results The effective pain-relieving rate was 92 % caused by permanent implantation of iodine 125 seeds. Of all the patients, 15 patients achieved complete response, 8 patients obtained partial response （PR）, and 2 patients had no change. The pain grade was decreased significantly after the treatment （P〈0.05）. Imaging examination showed that 9 le- sions had partial response, 16 lesions were stable, and 7 lesions were progressive 2 months after surgery. All the patients had no serious adverse reactions. Conclusion Permanent implantation of ＇z~I seeds has a definite effect on tumor metastasis and caused minimal damage and few complications. It is worthy of popularization in clinic.