256层螺旋CT脑灌注成像与颈内动脉狭窄的相关性研究

目的：应用256层螺旋CT探讨颈内动脉狭窄和闭塞与脑灌注降低的相关性。方法：对76例患者进行CTA和CTP联合检查,根据CTA图像选出颈内动脉无狭窄者为对照组,其余患者进行颈内动脉狭窄分级,分轻、中、重三级,每级独立分析研究。所有患者均选择感兴趣区进行脑灌注成像CBV、CBF、MTT、TTP测量,单侧颈内动脉狭窄者病变侧与健侧对比,进行配对t检验。双侧颈内动脉狭窄者与对照组对比,进行独立样本t检验。结果：颈内动脉无狭窄者共15例,CBV CBF MTT TTP值分别为（分水岭区2.5±0.6;38±12;5.4±0.6;21±6。基底节区5.5±0.4;95±15;3.2±1.1;20±5）。单侧颈内动脉狭窄者共33例,其中轻中度狭窄者各为12例,且CBV、CBF、MTT、TTP四项差异均无统计学意义（P〉0.05）,重度狭窄者9例,分水岭区CBF、MTT差异有高度统计学意义（P〈0.01）,TTP差异有统计学意义（P〈0.05）,CBV差异无统计学意义（P〉0.05）。基底节区MTT差异有高度统计学意义（P〈0.01）,CBF差异有统计学意义（P〈0.05）,CBV、TTP差异无统计学意义（P〉0.05）。双侧颈内动脉狭窄者共28例,重度狭窄者11例,CBF、MTT差异有统计学意义（P〈0.05）。结论：受侧枝循环等多种因素影响,颈内动脉重度狭窄或闭塞与脑内血流灌注降低有相关性,轻中度狭窄与脑灌注降低无明显相关性。

Application research about brain perfusion imaging and head and neck angiography in carotid artery stenosis on 256-slice spiral CT

Objective:To discuss the correlation of carotid artery stenosis and blocking with cerebral perfusion reduction on 256 spiral CT.Methods:76 patients underwent joint inspection of CTA and CTP.We selected the patients with no carotid artery stenosis as control group according to CTA images,the remaining patients were divided into three levels: mild,moderate and severe according to the degree of carotid artery stenosis,and each level was analysed,independently.All patients were selected the interest region to p...