| HGF和MMP-9在扁平苔藓皮损中的表达及意义 |
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| 引用本文： | 何肖,白莉. HGF和MMP-9在扁平苔藓皮损中的表达及意义[J]. 医学研究杂志, 2011, 40(3): 123-124 |
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| 作者姓名： | 何肖 白莉 |
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| 作者单位： | 山西医科大学第一医院皮肤科,太原,030001 |
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| 摘 要： | 目的检测扁平苔藓皮损中肝细胞生长因子(HGF)和基质金属蛋白酶-9(MMP-9)的表达情况,探讨其在扁平苔藓发病中的意义。方法应用免疫组化法和RT-PCR法测定30例扁平苔藓及30例正常皮肤组织中HGF和MMP-9的表达水平。结果扁平苔藓组中HGF和MMP-9的表达率均高于正常对照组(P<0.01),且二者在扁平苔藓皮损中的表达呈正相关(r1=0.391,P1=0.032;r2=0.375,P2=0.041)。结论 HGF和MMP-9的高表达可能参与了扁平苔藓的发病。
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| 关 键 词： | 扁平苔藓 肝细胞生长因子 基质金属蛋白酶-9 |
| 收稿时间： | 2010-09-16 |
The Expression and Significance of HGF and MMP-9 in Lichen Planus |
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| He Xiao,Bai Li. The Expression and Significance of HGF and MMP-9 in Lichen Planus[J]. Journal of Medical Research, 2011, 40(3): 123-124 |
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| Authors: | He Xiao Bai Li |
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| Affiliation: | He Xiao,Bai Li.Department of Dermatology,The First Hospital of Shan xi Medical University,Shanxi 030001,China |
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| Abstract: | Objective To explore the expression of hepatocyte growth factor(HGF) and metalloproteinase-9(MMP-9) in lichen planus,and investigate the function in pathogenesis of lichen planus.Methods The expression of HGF and MMP-9 was assayed by RT-PCR and immunohistochemistry in 30 LP lesions and 30 normal skins.Results The expression of HGF and MMP-9 in LP lesions was stronger than that in normal skins(P<0.01),and HGF was positively related to the expression of MMP-9 in LP lesions(r1=0.391,P1=0.032;r2=0.375,P2=0.041)... |
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| Keywords: | Lichen planus Hepatocyte growth factor Metalloproteinase-9 |
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