胃泌素、生长抑素与胃肠肿瘤细胞增殖和凋亡关系的研究进展

胃泌素使十二指肠细胞、小肠crypt细胞、结肠细胞的DNA合成增加,对结肠肿瘤细胞株有促生长作用,胃泌素拮抗剂可延缓肿瘤细胞的生长。生长抑素是维持胃肠激素环境稳定的重要激素,生长抑素及其类似物对许多实体肿瘤及正常组织有抗增生作用。胃泌素促进细胞增殖、抑制凋亡,生长抑素抑制细胞增殖、促进凋亡的作用,揭示了临床内分泌治疗的美好前景;胃肠激素及其类似物、胃肠激素拮抗剂用于临床治疗胃肠肿瘤可能为期不远。

Research Progress in Association of Somatostatin,Gastrin and Gastrointestinal Tumor Cell Proliferation and Apoptosis

Gastrin promotes the synthesis of DNA in duodenal cells,intestinal crypt cells,and colon cells.Gastrin also favors the growth of colon cancer cell lines,whereas gastrin receptor antagonist suppresses the growth of tumor cells.As a critical hormone maintaining gastrointestinal hormonal environment,somatostatin and analogues have an antiproliferative effect on many solid tumors and normal tissues.Gastrin promotes cell proliferation but suppresses apoptosis,whereas somatostatin suppresses cell proliferation bu...