| 红细胞生成素对单侧输尿管梗阻大鼠肾间质纤维化的影响 |
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| 引用本文： | 邓英辉,付文静,张沛.红细胞生成素对单侧输尿管梗阻大鼠肾间质纤维化的影响[J].医学综述,2011,17(3):457-459. |
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| 作者姓名： | 邓英辉 付文静 张沛 |
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| 作者单位： | 首都医科大学宣武医院肾内科,北京,100053 |
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| 摘 要： | 目的观察红细胞生成素(EPO)对单侧输尿管梗阻(UUO)大鼠肾间质纤维化的保护作用。方法选取36只SD大鼠随机分为对照组、模型组和EPO治疗组。模型组及治疗组大鼠行UUO术。治疗组大鼠于术前1天及术后第2、5、8天给予EPO(1000 U/kg)腹腔注射。术后第10天取术侧肾脏组织,观察大鼠肾脏皮质相对间质容积的变化。免疫组织化学方法检测转化生长因子β1、α平滑肌肌动蛋白和Ⅰ型胶原在肾间质中的表达。结果模型组和EPO治疗组出现明显的肾间质纤维化改变,但EPO治疗组病变程度较模型组减轻。模型组及EPO治疗组的肾皮质相对间质容积高于对照组(P<0.01),但EPO治疗组较模型组减低(P<0.01)。转化生长因子β1、α平滑肌肌动蛋白和Ⅰ型胶原于模型组和EPO治疗组中表达均高于对照组(P<0.01),但三者的表达于EPO治疗组均低于模型组(P<0.01)。结论 EPO可以减缓大鼠肾间质纤维化的进展,这种作用部分是通过抑制转化生长因子β1表达、阻止肾小管上皮细胞-间充质细胞转分化实现的。
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| 关 键 词： | 红细胞生成素 肾间质纤维化 转化生长因子 |
Effects of Erythropoietin on Renal Interstitial Fibrosis in Rats |
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| DENG Ying-hui,FU Wen-jing,ZHANG Pei.Effects of Erythropoietin on Renal Interstitial Fibrosis in Rats[J].Medical Recapitulate,2011,17(3):457-459. |
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| Authors: | DENG Ying-hui FU Wen-jing ZHANG Pei |
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| Institution: | DENG Ying-hui,FU Wen-jing,ZHANG Pei.(Department of Nephrology,Beijing Xuanwu Hospital,Capital Medical University,Beijing 100053,China) |
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| Abstract: | Objective To investigate the effect and mechanism of erythropoietin on renal tubulointerstitial fibrosis in rats with unilateral ureteral obstruction(UUO).Methods Thirtysix sprague-dawley rats were randomly divided into the control group(A),the UUO model group(B)and the treatment group(C).The group B and C were undertaken UUO operation.The treatment group rats were treated with intraperitoneal injection of Erythropoietin(1000 U/kg)at 1 day preoperation and at day 2,5 and 8 post-operation.On the 10th day of ... |
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| Keywords: | Erythropoietin Renal interstitial fibrosis Transforming growth factor-β1 |
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