非ST段抬高型急性冠脉综合征肌钙蛋白Ⅰ水平对危险分层的评估

目的:探讨血清肌钙蛋白Ⅰ(cTnI)对非ST段抬高型急性冠状动脉综合征(NSTEACS)患者危险分层的判断价值。方法:对82例NSTEACS患者、50例健康者分别进行血清cTnI测定,并观察NSTEACS患者住院1个月内心脏事件发生情况。结果:NSTEACS组血清cTnI值明显高于正常对照组(P0.01)。NSTEACS组内,心肌梗塞者(cTnI阳性亚组)血清cTnI值明显高于不稳定型心绞痛者(cTnI阴性亚组)(P0.01)。正常对照组无一例发生心脏事件;cTnI阳性亚组心脏事件发生率为17.3%,显著高于cTnI阴性亚组的5.5%(P0.05)。结论:血清cTnI水平对NSTEACS患者危险分层有较好的价值。

Risk assessment value of troponin I in patients with non-ST-segment elevation acute coronary syndrome

Objective：To evaluate the value of serum troponin I （cTnI）in risk stratification of patients with non-ST-segment elevation acute coronary syndrome（NSTEACS）.Methods：Serum cTnI levels were measured in 50 healthy subjects（control group）,and 82 NSTEACS patients respectively.Cardiac events（cardiac sudden death）were observed within l month of hospitalization.Serum cTnI≥1.5μg/L was considered as the cut off level for myocardial damage.Results：Serum cTnI levels in the NSTEACS group were higher than that in the control group[（1.98±0.11）μg/L vs.（0.49±0.10）μg/L,P〈0.01].In the NSTEACS group,serum cTnI levels in the non-ST-segment elevation acute myocardial infarct （NSTEMI） group were higher than that in the UAP group（P〈0.01）.No cardiac events happened in the control group;in the NSTEMI（cTnI≥1.5μg/L） and UAP group（cTnI〈1.5μg/L）,the rate of cardiac events was （17.3%vs.5.5%,P〈0.05）.Conclusion：The serum cTnI level has clinical value in risk assessment of patients with non-ST-segment elevation acute coronary syndrome.