| GP方案治疗RRM1蛋白低表达的晚期非小细胞肺癌的疗效观察(英文) |
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| 摘 要： | Objective:The aim of this study was to observe the efficacy of gemcitabine combined with cisplatin(GP)in advanced non-small cell lung cancer(NSCLC)patients with low expression of ribonucleotide reductase 1(RRM1)protein using immunohistochemistry.Methods:RRM1 protein expression in tumor tissue was detected by streptavidin-peroxidase (SP)method of immunohistochemistry.GP regimen(gemcitabine 1000-1250 mg d1,d8,cisplatin 75 mg/m2)was given to advanced NSCLC patients with low expression of RRM1 protein.Results:I...
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| 关 键 词： | 表达 治疗 蛋白 方案 晚期非小细胞肺癌 疗效观察 |
| 收稿时间： | 2008-12-04 |
Effects of gemcitabine and cisplatin chemotherapy in advanced non-small cell lung cancer patients with RRM1 low protein expression |
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| Meiling Zhao,Haihong Yang,Jun liu,Yubao Guan,Mingchong Mo,Enyun Lin,Jianxing He. Effects of gemcitabine and cisplatin chemotherapy in advanced non-small cell lung cancer patients with RRM1 low protein expression[J]. The Chinese-German Journal of Clinical Oncology, 2011, 10(12): 687-691. DOI: 10.1007/s10330-011-0874-8 |
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| Authors: | Meiling Zhao Haihong Yang Jun liu Yubao Guan Mingchong Mo Enyun Lin Jianxing He |
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| Affiliation: | (1) Department of Thoracic Medical Oncology, Peking University School of Oncology, Beijing Cancer Hospital and Institute, Beijing, 100036, China;(2) The Department of Thoracic/Head and Neck Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA;(3) Department of Biostatistics, Peking University School of Oncology, Beijing Cancer Hospital and Institute, Beijing, China |
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| Abstract: | Objective The aim of this study was to observe the efficacy of gemcitabine combined with cisplatin (GP) in advanced non-small cell lung cancer (NSCLC) patients with low expression of ribonucleotide reductase 1 (RRM1) protein using immunohistochemistry. |
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| Keywords: | gemcitabine ribonucleotide reductase 1(RRM1) immunohistochemistry chemotherapy non-small cell lung cancer(NSCLC) |
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