头孢硫脒联合美洛西林静脉滴注诱发大疱性表皮松解症

1例7岁女童为预防术后感染给予头孢硫脒2.0 g加入0.9%氯化钠溶液100 ml中静脉滴注,1次/d;美洛西林2.0 g加入5%葡萄糖注射液100 ml中静脉滴注,1次/d,共用药9 d。停药第2天,患儿出现全身瘙痒,伴散在皮疹、低热。之后皮疹进行性加重,呈弥散性紫红色,表面可见水疱、部分糜烂,以躯干为主,伴口腔黏膜、眼结膜糜烂及脓性渗出,遂入院。给予阿奇霉素、夫西地酸、甲泼尼龙、人免疫球蛋白及外用药治疗。患儿皮肤症状逐渐好转,2周后痊愈出院。

Epidermolysis bullosa due to an intravenous infusion of cefathiamidine combined with mezlocillin

A 7-year-old girl received anⅣinfusion of cefathiamidine 2.0 g in 0.9%sodium chloride 100 ml once daily and anⅣinfusion of mezlocillin 2.0 g dissolved in 0.5%glucose 100 ml once daily for nine days for preventing infection after surgery.On day 2 after withdrawl,the patient developed generalized pruritus accompanied by sporadic rashes and low-grade fever.Subsequently,her rash progressively worsen and became purple and more extensive;vesicles with erosion were seen on the lesion surface;the rash mainly involved her trunk,and erosion and purulent exudation were noted in the oral and conjunctival mucosa.She was then hospitalised and treated with azithromycin,fusidic acid,methylprednisolone,human immunoglobulin,and drugs for external use.Her symptoms of skin improved gradually and,two weeks later,she recovered and was discharged.