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| 头孢哌酮钠/舒巴坦钠静脉输注致严重凝血功能障碍 | |
| 引用本文： | 许亚梅,寇兰俊,杭海燕. 头孢哌酮钠/舒巴坦钠静脉输注致严重凝血功能障碍[J]. 药物不良反应杂志, 2011, 13(5): 315-316 |
| 作者姓名： | 许亚梅 寇兰俊 杭海燕 |
| 作者单位： | 1. 北京中医药大学附属东直门医院 血液科 ,北京,100700 2. 北京中医药大学附属东直门医院 急诊科,北京,100700 3. 北京中医药大学附属东直门医院 检验科,北京,100700 |
| 摘 要： | 1例76岁女性患者因肺部感染合并冠状动脉粥样硬化性心脏病给予静脉注射头孢哌酮钠/舒巴坦钠1.5 g、3次/d,生脉注射液40 ml/d,丹参酮ⅡA磺酸钠注射液60 mg/d,单硝酸异山梨酯注射液10 mg/d。治疗第4天患者出现凝血功能异常,凝血酶原时间(PT)58.4 s,凝血酶原活动度(PTA)13%,国际标准化比值(INR)3.83,活化部分凝血活酶时间(APTT)38.5 s。第5天停用丹参酮ⅡA磺酸钠注射液。第7天患者凝血功能障碍加重,PT 105.8 s,PTA 5.8%,INR 7.02,APTT 49.7 s。第12天,因考虑凝血功能障碍可能与头孢哌酮钠/舒巴坦钠输注相关,立即停药,其余治疗药物继续应用。患者当晚出现全程肉眼血尿,颏部可见瘀斑。第13天患者呕吐鲜血,APTT 99.4 s,立即输注新鲜冰冻血浆,静脉滴注卡络磺钠,肌内注射维生素K1。第15天患者复查凝血功能:PT 11.00 s,PTA 123.3%,INR 1.048,APTT 30.10 s。 |
| 关 键 词： | 头孢哌酮钠/舒巴坦钠 凝血功能障碍 |
Severe coagulation disorders caused by an intravenous infusion of cefoperazone sodium and sulbactam sodium |
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| Xu Yamei,Kou Lanjun,Hang Haiyan. Severe coagulation disorders caused by an intravenous infusion of cefoperazone sodium and sulbactam sodium[J]. Adverse Drug Reactions Journal, 2011, 13(5): 315-316 | |
| Authors: | Xu Yamei Kou Lanjun Hang Haiyan |
| Affiliation: | Xu Yamei1a,Kou Lanjun1b,Hang Haiyan1c(1aDepartment of Hematology,1bDepartment of Emergency,1cDepartment of Clinical Laboratory,Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine,Beijing 100700,China) |
| Abstract: | A 76-year-old woman received an IV infusion of cefoperazone sodium and sulbactam sodium 1.5 g thrice daily,IV Shengmai 40 ml,IV sulfotanshinone sodium 60 mg,and IV isosorbide mononitrate 10 mg for pulmonary infection and coronary heart disease.On day 4 of treatment,she developed coagulation disorders.Laboratory tests revealed a prothrombin time(PT) of 58.4 s,a prothrombin activity(PTA) of 13%,an international normalized ratio(INR) of 3.83,and a thromboplastin time(APTT) of 38.5 s.On day 5,sulfotanshinone so... |
| Keywords: | cefoperazone sodium and sulbactam sodium coagulation disorders |
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