高度近视LASEK术中应用丝裂霉素C预防haze的意义

目的探讨准分子激光上皮下角膜磨镶术（LASEK）术中联合应用丝裂霉素C（MMC）对术后角膜上皮下雾状浑浊（haze）的预防作用。方法随机对60例（120眼）高度近视（-6．00D以上）左右眼分别做单纯LASEK手术和LASEK＋MMC手术，观察6个月，计算}hhaze反应的发生率并进行比较。结果统计术后1、3、6个月haze的发生率，单纯LASEK分别为：0．5级，58．33％、48．33％、40．00％；1级，13．33％、8．33％、5．00％；2级，0、1．67％、1．67％；3级以上均为0。LASEK＋MMC分别为：0．5级，36．67％、26．67％、13．33％；1级，1．67％、1．67％、3．33％；2级以上均为0。两组比较差异有统计学意义（P〈0．05）。结论LASEK术中应用MMC能减轻haze反应形成，情况显著优于单纯LASEK手术。

A clinical observation of applying mitomycin C in LASEK surgery to prevent the formation of subepithelial corneal haze in patients with high myopia

Objective To observe the applying of mitomycin C in LASEK surgery to prevent the formation of subepithelial corneal haze in patients with high myopia.Methods Sixty patients ( 120 eyes) with high myopia were randomly performed LASEK on one eye,and they were performed 0.02％ mitomycin C treatment during LASEK on the other eye separately.Regular follow-up of 6 month was done to observe the haze formation.Results In the LASEK group,the rate of the haze of grade 0.5 was 58.33％,48.33％,40.00％ in 1 month,3 months and 6 months,that of grade 1 was 13.33％,8.33％,5.00％,that of grade 2 was 0,1.67％,1.67％,that of grade 3 and 4 was 0.In the LASEK + MMC group,the rate of the haze of grade 0.5 was 36.67％,26.67％,13.33％ in 1 mouths,3 months and 6 months respectively,that of grade 1 was 1.67％,1.67％,3.33％,that of grade 2,3 and 4 was 0.There was significant difference (P＜0.05) in the haze between the two groups.Conclusion The occurrence of the haze in the LASEK + MMCgroup is milder than that in the LASEK group.