两种浓度丝裂霉素C在LASEK术中预防haze效果的临床对比研究

目的探讨0．01％丝裂霉素c在LASEK术中预防术后haze形成的效果。方法随机对照的前瞻性临床研究。接受LASEK手术的137例，随机分为两组：对照组69例（137眼）术中用0．02％丝裂霉素C，观察组68例（136眼）术中用0．01％丝裂霉素C，分别浸润切削基质面。观察术后1个月、3个月、6个月时视力、屈光状态、haze形成情况及并发症。结果两组术后2周裸眼视力大部分达到或接近术前最佳矫正视力，术后6个月视力恢复情况符合美国FDA关于屈光手术有效性和安全性的评价标准。两组间在相同随访时间haze的发生情况差别无统计学意义。按照切削深度选择MMC作用时间后，在切削深度相同时，两组间haze出现情况差别无统计学意义。结论LASEK术中应用0．01％MMC并根据切削深度选择作用时间能有效地抑制haze的形成。

Clinical comparison of the effects of mitomycin C with two different concentrations on preventing haze after LASEK

Objective To investigate the effects of 0.01％ Mitomycin-C on preventing corneal haze after laser epithelial keratectomileusis(LASEK).Methods Perspective randomized case-control study was done.137 cases accepted LASEK were randomly divided into two groups,the control group which included 69 cases ( 137 eyes)were treated with 0.02％ mltomycin C,the study group which included 68 cases ( 136eyes) were treated with 0.01％ mitomycin C intraoperation respectively.And the applied time was chosen according to ablation depth.The postoperative uncorrected visual acuity (UCVA),refraction,corneal haze and complications were observed in one month,3 months and 6 months after operation.Results For the most cases,the UCVA was above or equal to preoperative UCVA two weeks postoperatively.The recovery of the visual acuity was accorded to the standard of FDA 6 months after surgery.The haze incidence was not statistically different between the two groups at the same follow-up time.And there was no statistical difference between the two groups with the same corneal ablation depth.Conclusion 0.01 ％ mitomycin C with a chosen application time according to the ablation depth can effectively inhibit corneal haze incidence of LASEK.