头孢呋辛静脉滴注致血小板减少

1例70岁女性患者拟行脑膜瘤切除术,术前因肺部感染给予头孢呋辛2 g溶于0.9%氯化钠溶液250ml,1次/d静脉滴注。用药前血小板166×10~9/L,用药第2天血小板急剧下降至40×10~9/L,但无临床出血表现。考虑可能与头孢呋辛有关,遂停用该药,改用氧氟沙星,换药1d后血小板上升至160×10~9/L。随后肺部感染好转,手术顺利完成。

Thrombocytopenia induced by intravenous infusion of cefuroxime

A 70-year-old woman was planned to undergo meningeoma resection and received an IV infusion of cefuroxime 2 g dissolved in 250 ml of 0.9% sodium chloride once daily for a lung infection before operation. Her platelet count was 166 ×10^9/L before drug administration and, on day 2 of treatment, her platelet count rapidly dropped to 40 ×10^9/L, but no evidence of clinical bleeding. It was considered to be associated with eefuroxime, so the drug was withdrawn and switehed to ofloxaein. One day after change to ofloxaein, her platelet count rose to 160 ×10^9/L. Thereafter, the pulmonary infection improved and the operation completed uneventfully.