| Institution: | 1. Traditional Chinese Medicine Department of Internal Medicine, Zhongda Hospital affiliated to Southeast University, Nanjing 210009, China;2. Internal Medicine Department of Traditional Chinese Medicine, Medicine School of Southeast University, Nanjing 210009, China;3. Outpatient Department, Hospital of Nanjing University of Posts and Telecommunications, Nanjing 210023, China |
| Abstract: | OBJECTIVETo evaluate the effect of Guizhi Gancao Longgu Muli Tang (GGLMT), a decoction prepared with herbal medicine of Traditional Chinese Medicine, on sleep disturbances in women with menopause.METHODSTotally 162 participants were recruited for the treatment of sleep difficulty from February, 2012 to December, 2014. Decoction of 200 mL was taken by every participant twice daily in half an hour after lunch and dinner during two weeks. Sleep quality was assessed by Pittsburg sleep quality index (PSQI) and menopausal symptoms and quality of life were evaluated by the menopause rating scale (MRS) and the Chinese version of World Health Organization quality of life-BREF at the final fellow-up in the fourth weekend after beginning.RESULTSThe average scores of PSQI had reduced from (13.82 ± 4.97) to (8.14 ± 3.19), 95% CI (? 4.87, ? 3.05) after 2-week GGLMT treatment in the fourth week. GGLMT improved symptoms in patients with more severe conditions (MRS ≥ 16). Three adverse drug reaction, mouth ulcer, constipation, and folliculitis, might be related with GGLMT and disappeared after withdrawals of the treatment.CONCLUSIONFor menopausal women suffering from chronic sleep disturbances, our findings suggest that two weeks treatment of GGLMT was safe and effective. |
