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Allergic conversion of protective mucosal immunity against nasal bacteria in patients with chronic rhinosinusitis with nasal polyposis |
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| Authors: | Kazuya Takeda Shuhei Sakakibara Kazuo Yamashita Daisuke Motooka Shota Nakamura Marwa Ali El Hussien Jun Katayama Yohei Maeda Masanobu Nakata Shigeyuki Hamada Daron M Standley Masaki Hayama Takashi Shikina Hidenori Inohara Hitoshi Kikutani |
| Institution: | 1. Laboratory of Immune Regulation, Immunology Frontier Research Center, Osaka, Japan;3. Laboratory of System Immunology, Immunology Frontier Research Center, Osaka, Japan;4. Department of Infection Metagenomics, Genome Information Research Center, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan;7. Department of Genome Informatics, Genome Information Research Center, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan;6. Thailand-Japan Research Collaboration Center on Emerging and Re-emerging Infections, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan;2. Department of Otorhinolaryngology–Head and Neck Surgery, Osaka University Graduate School of Medicine, Osaka, Japan;5. Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Osaka, Japan |
| Abstract: |  |
| Keywords: | Chronic rhinosinusitis with nasal polyposis IgE human mAb high-throughput immunoglobulin analysis AID Activation-induced deaminase BCL-6 B-cell lymphoma 6 CMV Cytomegalovirus CRSwNP Chronic rhinosinusitis with nasal polyposis CSR Class-switch recombination CTV CellTrace Violet GC Germinal center HTS High-throughput DNA sequencing ICOS Inducible costimulator LTA Lipoteichoic acid NP Nasal polyp PD-1 Programmed cell death protein 1 SE Staphylococcal enterotoxin SHM Somatic hypermutation Follicular helper T VH Variable region of immunoglobulin heavy chain |
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