Effect of Low-Intensity Pulsed Ultrasound on a Rat Model of Dentin–Dental Pulp Injury and Repair |
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| Authors: | Fei Wang Yueheng Li Zhengyan Yang Keke Lu Jing Zuo Zhi Zhou |
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| Institution: | The College of Stomatology, Chongqing Medical University, Chongqing, China; Chongqing Key Laboratory for Oral Diseases and Biomedical Science, Chongqing, China; and Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing, People’s Republic of China |
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| Abstract: | This study investigated histopathologic changes in dental pulp after treatment with low-intensity pulsed ultrasound (LIPUS). Fifty rats were randomly divided into an experimental group (n = 25) and a blank control group (n = 25). In the experimental group, a cavity was prepared in the bilateral maxillary first molars. The upper right first molars were stimulated with LIPUS (30 mW/cm2, 1.5 MHz) for 20 min/d. The cavities prepared in the left teeth were used as experimental controls (i.e., no LIPUS). Five rats in each group were sacrificed at days 1, 3, 5, 7 and 14. Inflammatory response was visible at different time points after cavity preparation, peaking at day 3, after which it gradually weakened. More reparative dentin was found on the LIPUS treatment side. transforming growth factor-β1 expression increased after treatment, peaking at day 5 and returning to normal at day 14 on both sides, but was stronger with LIPUS treatment. SMAD2 and SMAD3 expressions in the dental pulp gradually increased after cavity preparation, especially in the experimental group. LIPUS promoted the repair of dentin–pulp complex injury, to a certain extent and should be investigated further as a potential therapy. |
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| Keywords: | Low-intensity pulsed ultrasound Dentin–pulp complex transforming growth factor-β1 SMAD2 SMAD3 |
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