| 前列腺素E2对新生大鼠呼吸影响的机制研究 |
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| 引用本文： | 成 问,孙明洁,王儒蓉,等.前列腺素E2对新生大鼠呼吸影响的机制研究[J].西部医学,2014(2):138-141. |
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| 作者姓名： | 成 问 孙明洁 王儒蓉 等 |
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| 作者单位： | [1]四川大学华西医院麻醉科,四川成都610041 [2]遵义医学院麻醉系,贵州遵义563003 |
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| 基金项目： | 国家自然科学基金（81170077） |
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| 摘 要： | 目的 探讨SD新生大鼠右心房注射前列腺素E2 （PGE2）产生呼吸暂停的作用机制.方法 将24只7～9天的SD大鼠随机分为3组,分别在右心房注射辣椒平、S-3144（P物质受体拮抗剂）和AH6809（前列腺素E2受体拮抗剂）前后注射PGE2,观察呼吸指标的变化.结果 右心房注射PGE2在7～9天大鼠引起呼吸暂停;AH6809可缩短PGE2产生的呼气时间约42％ （P＜0.05）,但辣椒平和S-3144对PGE2产生的呼吸暂停无明显影响.结论 新生大鼠右心房注射PGE2引起呼吸暂停,是通过作用于前列腺素E2（EP2）受体产生而与辣椒素受体和P物质受体无关.
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| 关 键 词： | 前列腺素E2 AH6809 呼吸暂停 |
The mechanism of PGE2 induced respiratory alteration in neonatal rats |
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| Institution: | CHENG Wen , SUN Ming-jie , WANG Ru-rong , et al Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China ; 2. Department of Anesthesiology, Zunyi Medical College, Zunyi 563003, Guizhou, China) |
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| Abstract: | Objective To explore the possible mechanism of right atrial injection of prostaglandin E2 （PGE2） on respiratory response in neonatal Sprague Dawley rats. Methods 24 SD rats at postnatal day 7-9（ P7- 9） received bo- lus injection of PGE2 before and after capsazepine, S-a144 （antagonist of NK1 receptor）, and AH6809 （antagonist of EP2 receptor） injection from the right atrium. The ventilatory alterations were observed and analyzed. Results Right at- rial bolus injection of PGEz generated apnea in PT 9 rats. AH6809 could evidently reduce the duration of expiration in- duced by PGE2 approximately 42~ （P〈0.05）, but capsazepine and S-3144 could not change. Conclusion Apnea induced by the right atrial injection of PGFe is partially induced by activating EP2 receptor but not capsaicin and neurokinin 1 receptors. |
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| Keywords: | PGE2 AH6809 Apnea |
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