Female fertility preservation in the pediatric and adolescent cancer patient population |
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| Affiliation: | 1. University of Pittsburgh School of Medicine, 3550 Terrace St., Pittsburgh, PA 15213, USA;2. Department of Obstetrics, Gynecology & Reproductive Sciences, University of Pittsburgh School of Medicine, 300 Halket St., Suite 5150, Pittsburgh, PA 15213, USA;3. Department of Obstetrics, Gynecology & Reproductive Sciences, University of Pittsburgh School of Medicine, 204 Craft Ave, Pittsburgh, PA 15213, USA;1. Division of Pediatric & Adolescent Gynecology, Children''s Hospital of Pittsburgh, University of Pittsburgh Medical Center, 4401 Penn Ave, Pittsburgh, PA 15224, USA;2. Department of Obstetrics/Gynecology, Carilion Clinic/Virginia Tech-Carilion School of Medicine, 1906 Belleview Ave, Roanoke, VA 24014, USA;1. Department of Psychology, Saint Vincent College, Latrobe, PA, USA;2. Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA, USA;1. Department of Psychology, St. Jude Children''s Research Hospital, Memphis, Tennessee;2. University of Tennessee College of Medicine, Memphis, Tennessee;3. Department of Biostatistics, St. Jude Children''s Research Hospital, Memphis, Tennessee;4. Department of Behavioral Science, MD Anderson Cancer Center, Houston, Texas;5. Department of Surgery, St. Jude Children''s Research Hospital, Memphis, Tennessee;6. Fertility Associates of Memphis, Memphis, Tennessee;1. Boyne Research Institute, 5 Bolton Square, East, Drogheda, Co. Louth A92 RY6K, Ireland;2. German Childhood Cancer Registry (GCCR), Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center, Mainz, Germany;3. Pintail Ltd, Dublin, Ireland;4. Department of Paediatrics &- Oncology, Hematology and Immunology, Centre for Paediatric, Adolescent and Women''s Medicine, Klinikum Stuttgart – Olgahospital, Stuttgart, Germany;5. Department for Phoniatrics and Pedaudiology, Universitätsklinikum, Münster, Germany;6. Department of Paediatric Haematology and Oncology Universitätsklinikum, Bonn, Germany;7. Department Pediatric Oncology, Emma Children''s Hospital/Academic Medical Center (AMC), Amsterdam, The Netherlands;8. Prinses Máxima Center for Paediatric Oncology, Utrecht, The Netherlands;9. Paediatric Oncology and Hematology, University Hospital for Children and Adolescents, University zu Lübeck, Lübeck, Germany;10. Erasmus MC – Sophia Children''s Hospital, Rotterdam, The Netherlands;11. Amsterdam UMC, Vrije Universiteit Amsterdam, Pediatrics, Cancer Centre Amsterdam, Amsterdam, The Netherlands;12. Danish Cancer Society Research Center, Copenhagen, Denmark;13. Klinik für Kinder und Jugendliche, Friedrich-Alexander- Universität, Erlangen, Nürnberg, Germany;14. Department of Paediatric Hematology and Oncology Unit, University Hospital of Saint-Étienne, Saint-Étienne, France;15. Epidemiology of Childhood and Adolescent Cancers, CRESS, INSERM, UMR 1153, Paris Descartes University, Villejuif, France;p. Institute of Medical Biometry and Statistics, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany;q. Charité - Universitätsmedizin, Berlin, Germany;r. Department of Paediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm, Germany;s. Pediatrics III, Pediatric Hematology and Oncology, West German Cancer Centre, University Hospital, Essen, Germany;t. Department of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark;u. Institutt for Klinisk Medisin, Universitetet I Oslo, Oslo, Norway;v. University College London Hospital, London, UK;w. Epidemiology and Biostatistics Unit and Italian Off-Therapy Registry (OTR), Istituto Giannina Gaslini, Via Gerolamo Gaslini, 5, 16148, Genova, Italy;x. Department of Paediatrics, Lund University, Skåne University Hospital, Lund, Sweden;y. University Hospital Brno, Brno, Czech Republic;z. International Clinical Research Center (FNUSA-ICRC), Brno, Czech Republic;11. Institute of Public Health, University of Copenhagen, Copenhagen, Denmark;12. Medical University of Bialystok, Bialystok, Poland;13. Motol Teaching Hospital, Prague, Czech Republic;14. Swiss Childhood Cancer Registry, Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland;15. Department of Paediatric Oncology, Haematology and Immunology, Medical Faculty, Heinrich-Heine-University of Düsseldorf, Düsseldorf, Germany;16. Department of Paediatrics and Adolescent Medicine, Medical University of Graz, Graz, Austria;17. Great Ormond Street Children''s Hospital, London, UK;18. Department of Pediatric Oncology/Hematology, University of Groningen, Beatrix Children''s Hospital, University Medical Center Groningen, Groningen, the Netherlands;19. Edmond and Lily Safra Children''s Hospital, Chaim Sheba Medical Center, Tel Hashomer, Israel;110. The Sakler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel;111. Institute for the History, Philosophy, and Ethics of Medicine, Johannes Gutenberg University Center Mainz, Mainz, Germany;112. Klinika Pediatrii, Hematologii I Onkologii, Medical University, Gdansk, Poland;113. Helios Kliniken Berlin-Buch, Klinik Für Kinder-und Jungendmedizin, Berlin, Germany;114. Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands;115. Institute of Pharmacology of Natural Products and Clinical Pharmacology, University Hospital Ulm, Ulm, Germany;1. Division of Urology, Ann and Robert H. Lurie Children’s Hospital of Chicago™, Chicago, Illinois;2. Division of Endocrinology, Ann and Robert H. Lurie Children’s Hospital of Chicago™, Chicago, Illinois;3. Division of Pediatric Surgery, Ann and Robert H. Lurie Children’s Hospital of Chicago™, Chicago, Illinois;4. Division of Hematology/Oncology, Ann and Robert H. Lurie Children’s Hospital of Chicago™, Chicago, Illinois;5. Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois;6. Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois;7. Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois;8. Department of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, Chicago, Illinois;9. Department of Obstetrics, Gynecology and Reproductive Sciences, Pittsburgh, Pennsylvania;10. Magee-Women’s Research Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania |
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| Abstract: | The 5-year survival rate for childhood cancer is over 80%, thereby increasing the number of young women facing infertility in the future because of the gonadotoxic effects of chemotherapy and radiation. The gonadotoxic effects of childhood cancer treatment vary by the radiation regimen and the chemotherapeutic drugs utilized. Although the American Society of Clinical Oncology guidelines recommend fertility preservation for all patients, there are several barriers and ethical considerations to fertility preservation in the pediatric and adolescent female population. Additionally, the fertility preservation methods for pre- and postpubertal females differ, with only experimental methods available for prepubertal females. We will review the risk of chemotherapy and radiation on female fertility, the approach to fertility preservation in the pediatric and adolescent female population, methods of fertility preservation for both pre- and postpubertal females, barriers to fertility preservation, cost, and psychological and ethical considerations. |
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| Keywords: | Fertility preservation Cancer Pediatric Adolescent Cryopreservation |
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