Influence of valproate on language functions in children with epilepsy |
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| Affiliation: | 1. Dept. of Pediatrics, Chonbuk National University Medical School, Jeonju 54907, Republic of Korea;2. Research Institute of Clinical Medicine, Chonbuk National University Medical School, Jeonju 54907, Republic of Korea;1. Neurological Clinic, Marche Polytechnic University, Ancona, Italy;2. Internal and Subintensive Medicine, Ospedali Riuniti Ancona, Italy;1. Laboratory of Clinical Neurophysiology, Psychiatry Department, University of São Paulo (USP) School of Medicine, São Paulo, SP, Brazil;2. Group for the Study of Cognitive and Psychiatric Disorders in Epilepsy—Clinics Hospital, University of São Paulo (USP), Brazil;3. Department of Neurology, University of Campinas (UNICAMP), Campinas, SP, Brazil;4. Center for Interdisciplinary Research on Applied Neurosciences (NAPNA), University of São Paulo (USP), Brazil;1. University of Washington Neurology Vocational Services Unit/Epilepsy Center, Department of Rehabilitation Medicine, Seattle, WA, United States;2. Surgical Epilepsy Program, California Pacific Medical Center, San Francisco, CA, United States;3. University of California, San Francisco, United States;4. Epilepsy Program, California Pacific Medical Center, San Francisco, CA, United States;5. PEP Jobs Program, California Pacific Medical Center, San Francisco, CA, United States;1. Department of Medicine, The University of Melbourne, Parkville, Australia;2. Department of Neurology, Royal Melbourne Hospital, Parkville, Australia;3. Department of Neuropathology, Royal Prince Alfred Hospital, NSW, Australia;4. Brain & Mind Centre, University of Sydney, NSW, Australia;5. Department of Anatomical Pathology, Royal Melbourne Hospital, Parkville, Australia;6. Department of Surgery, The University of Melbourne, Parkville, Australia;7. Department of Neurosurgery, Royal Melbourne Hospital, Parkville, Australia;1. State Key Laboratory of Reliability and Intelligence of Electrical Equipment, School of Electrical Engineering, Hebei University of Technology, 369#, Tianjin 300130, China;2. Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA;3. Department of Nuclear Medicine, Fuzhou General Hospital, No. 156, Second West Ring Road, Fuzhou 350025, China;4. Liaoyuan Hospital of Traditional Chinese Medicine, Liaoyuan 136200, China;5. Institute for Research and Medical Consultations, Imam Abdulahman Bin Faisal University, Dammam, Saudi Arabia;1. Neurology Clinic, University Hospital of Perugia, Perugia, Italy;2. IRCCS “Santa Lucia”, Rome, Italy |
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| Abstract: | The aim of the current study was to assess the influences of valproate (VPA) on the language functions in newly diagnosed pediatric patients with epilepsy. We reviewed medical records of 53 newly diagnosed patients with epilepsy, who were being treated with VPA monotherapy (n = 53; 22 male patients and 31 female patients). The subjects underwent standardized language tests, at least twice, before and after the initiation of VPA. The standardized language tests used were The Test of Language Problem Solving Abilities, a Korean version of The Expressive/Receptive Language Function Test, and the Urimal Test of Articulation and Phonology. Since all the patients analyzed spoke Korean as their first language, we used Korean language tests to reduce the bias within the data. All the language parameters of the Test of Language Problem Solving Abilities slightly improved after the initiation of VPA in the 53 pediatric patients with epilepsy (mean age: 11.6 ± 3.2 years), but only “prediction” was statistically significant (determining cause, 14.9 ± 5.1 to 15.5 ± 4.3; making inference, 16.1 ± 5.8 to 16.9 ± 5.6; prediction, 11.1 ± 4.9 to 11.9 ± 4.2; total score of TOPS, 42.0 ± 14.4 to 44.2 ± 12.5). The patients treated with VPA also exhibited a small extension in mean length of utterance in words (MLU-w) when responding, but this was not statistically significant (determining cause, 5.4 ± 2.0 to 5.7 ± 1.6; making inference, 5.8 ± 2.2 to 6.0 ± 1.8; prediction, 5.9 ± 2.5 to 5.9 ± 2.1; total, 5.7 ± 2.1 to 5.9 ± 1.7). The administration of VPA led to a slight, but not statistically significant, improvement in the receptive language function (range: 144.7 ± 41.1 to 148.2 ± 39.7). Finally, there were no statistically significant changes in the percentage of articulation performance after taking VPA. Therefore, our data suggested that VPA did not have negative impact on the language function, but rather slightly improved problem-solving abilities. |
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