| 加压素在脑缺血再灌流海马迟发性神经元损伤中的作用 |
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| 引用本文： | 刘新峰,金泳清.加压素在脑缺血再灌流海马迟发性神经元损伤中的作用[J].解放军医学杂志,1994,19(5):345-347. |
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| 作者姓名： | 刘新峰 金泳清 |
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| 作者单位： | 南京军区南京总医院 |
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| 摘 要： | 用沙土鼠制作迟发性神经元损伤动物模型。结果表明，脑缺血再灌流６－９６小时，海马ＣＡＩ区ＡＶＰ含量以及再灌流２６－９６小时的ＣＡＩ区含水量持续性增高。向侧脑室注射ＡＶＰ后，再灌流９６小时的海马ＣＡＩ区含水量和Ｃａ＾２＋浓度均较生理盐水对照组显著增加，而Ｎａ＾＋，Ｋ＾＋－ＡＴＰ酶活力却明显降低；侧脑室注射ＡＶＰ抗血清后，海马 ＣＡＩ区含水量和Ｃａ＾２＋浓度较对照组显著降低。
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| 关 键 词： | 脑缺血 海马 加压素 钙 |
EFFECT OF VASOPRESSIN ON DELAYED NEURONAL DAMAGE IN HIPPOCAMPUS FOLLOWING CEREBRAL ISCHEMIA AND REPERFUSION IN GERBILS |
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| LiuXinfeng,Jin Yongqing.EFFECT OF VASOPRESSIN ON DELAYED NEURONAL DAMAGE IN HIPPOCAMPUS FOLLOWING CEREBRAL ISCHEMIA AND REPERFUSION IN GERBILS[J].Medical Journal of Chinese People's Liberation Army,1994,19(5):345-347. |
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| Authors: | LiuXinfeng Jin Yongqing |
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| Institution: | LiuXinfeng,Jin Yongqing. General Hospital of Nanjing Command,PLA. Nanjin 210002 |
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| Abstract: | Mongolian gerbils were used as animal model of delayed neuronal damage(DND). The results showed that AVP , contents of CA 1 sector of hippocampus dUring 6 to 96 hours recirculation , and the water content of CA1 sector during 24 to 96 hours recirculation were significantly and continuously increased. After ICV of AVP, the water content and calciurn in CA1 sector of hippocampus at the period of cerebral ischemia and 96 hours recirculation further increased,and the Na+,K+-ATPase activity in CA 1 sector decreased remarkably as compared with that of control. While in cases of ICV of AVP antiserum, the water content and calcium in CA1 sector decreased significantly as compared with that of control. |
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