Glutathione transferase T1 and M1 genotype polymorphism in the normal population of Shanghai |
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| Authors: | Jianhua Shen Goufang Lin Wuxing Yuan Jingwei Tan Hermann M. Bolt Ricarda Thier |
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| Affiliation: | Sino-German Laboratory of Toxicology (DCLT), Shanghai Institute of Entomology, Chinese Academy of Sciences, Shanghai 200 025, Republic of China, CN
Institut für Arbeitsphysiologie an der Universit?t Dortmund, D-44139 Dortmund, Germany, DE
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| Abstract: | Glutathione transferases are known to be important enzymes in the metabolism of xenobiotics. In humans genetic polymorphisms have been reported for the hGSTM1 and hGSTT1 genes leading to individual differences in susceptibility towards toxic effects, such as cancer. This study describes the distribution of the two polymorphisms of hGSTT1 and hGSTM1 in the normal Chinese population of Shanghai. Out of 219 healthy individuals having been genotyped for GSTT1 and GSTM1, 108 (49%) were identified to be homozygously deficient for the GSTT1 gene and 107 (49%) for the GSTM1 gene. Received: 26 January 1998 / Accepted: 8 April 1998 |
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| Keywords: | Glutathione transferase GSTT1 GSTM1 Polymorphism |
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