国产利福昔明治疗急性细菌性肠道感染随机对照试验的Meta分析 |
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引用本文: | 方宝霞,陈富超,李鹏,时晓亚.国产利福昔明治疗急性细菌性肠道感染随机对照试验的Meta分析[J].中国药物应用与监测,2010,7(2):76-79. |
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作者姓名: | 方宝霞 陈富超 李鹏 时晓亚 |
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作者单位: | 郧阳医学院附属东风总医院药学部,湖北,十堰,442008 |
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摘 要: | 目的:探讨国产利福昔明治疗急性细菌性肠道感染的有效性和安全性。方法:按照系统评价的要求,全面检索了1994年1月-2008年12月中国医院数字图书馆、中文科技期刊数据库,对符合纳入标准的l5篇文献共计2443名患者的相关疗效指标进行了Meta分析。结果:与环丙沙星、左氧氟沙星相比,国产利福昔明治疗急性细菌性肠道感染的痊愈率、有效率、细菌清除率差异均无统计学意义(P〉0.05);国产利福昔明不良反应发生率为3.29%(39/1184),与对照药物比较差异无统计学意义OR合并=0.93,95%CI为0.60~1.44,P=0.74]。结论:目前国内证据表明,与环丙沙星、左氧氟沙星相比,国产利福昔明治疗急性细菌性肠道感染疗效无显著性差异。
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关 键 词: | 利福昔明 随机对照试验 细菌性肠道感染 Meta分析 |
Meta-analysis on randomized control trials of indigenous rifaximin in the treatment of acute infectious diarrhea |
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Authors: | FANG Bao-xia CHEN Fu-chao LI Peng SHI Xiao-ya |
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Institution: | FANG Bao-xia,CHEN Fu-chao,LI Peng,SHI Xiao-ya(Department of Pharmacy,Dongfeng General Hospital Affiliated to Yunyang Medical College,Shiyan 442008,China) |
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Abstract: | Objective:To estimate the efficacy and safety of indigenous rifaximin in the treatment of acute infectious diarrhea. Methods: Based on the principles and methods of systematic reviews, we searched Chinese Hospital Digital Database and VIP from January 1994 to December 2008. Meta-analysis was performed on the related clinical indexes of 2443 patients involved in 15 papers which met the inclusion criteria. Results: The clinical cure rates, clinical effective rates, corresponding bacterial eradication rates of... |
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Keywords: | Rifaximin Randomized control trial Infectious diarrhea Meta-analysis |
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