高压氧对颅脑损伤鼠内皮素及降钙素基因相关肽的影响 |
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引用本文: | 于涛,方以群,刘长云,李斌.高压氧对颅脑损伤鼠内皮素及降钙素基因相关肽的影响[J].实用医药杂志(山东),2008,25(4):471-473. |
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作者姓名: | 于涛 方以群 刘长云 李斌 |
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作者单位: | [1]401医院航海病中心,山东青岛266071 [2]海军医学研究所舰艇卫生研究室,上海200433 |
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摘 要: | 目的观察高压氧(HBO)治疗急性颅脑损伤大鼠血浆和损伤皮层内皮素(ET)和降钙素基因相关肽(CGRP)含量的变化。方法32只SD大鼠,随机为分正常组,急性颅脑损伤组(分颅脑损伤后6、24、48h组),高压氧治疗组(分颅脑损伤后6、24、48h组),常氧高氮处理组(分颅脑损伤后6、24、48h组)。每组各8只大鼠。各组动物出舱后按时间要求尽量在安静状态下快速断头取血及损伤皮层,采用放免法测定血浆及损伤皮层ET及CGRP含量。结果SD大鼠急性颅脑损伤后,其血浆和损伤皮层组织ET含量有不同程度的升高,而CGRP含量有不同程度的降低;高压氧治疗后,各组血浆及损伤皮层组织ET含量均有不同程度地降低,而血浆及损伤皮层CGRP含量亦有不同程度升高。结论急性颅脑损伤的发生发展与血浆和损伤皮层组织ET含量升高和CGRP含量降低有关;高压氧治疗可能通过降低ET含量和升高CGRP含量,从而起到治疗急性颅脑损伤的作用
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关 键 词: | 高压氧 内皮素 降钙素基因相关肽 急性颅脑损伤 |
The effects of hyperbaric oxygen therapy on the levels of endothelin and calcitonin gene-related peptide in the acute cerebral injury rats |
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Abstract: | Objective To study the effects of hyperbaric oxygen therapy(HBO) on plasma and levels of endothelin(ET) and calcitonin gene- related peptide(CGRP) in injuried cortex of rats with the acute cerebral injury(ACI). Methods Thirty-two Sprague-Dawley rats were randomly divided into four groups: normal group, ACI group, ACI+normoxic hyperbaric nitrogen group and ACI+HBO group. The last three groups were also divided into three subgroups according to the time schedule. The ACI rats was performed according to the ad... |
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Keywords: | Hyperbaric oxygenation Endothelin(ET) Calcitonin gene-related peptide(CGRP) Acute cerebral injury |
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