Bacterial vaginosis as a risk factor for high-grade cervical lesions and cancer in HIV-seropositive women |
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| Authors: | Sheri A. Denslow Cynthia Firnhaber Pam Michelow Jennifer S. Smith |
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| Affiliation: | a Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, USAb Department of Obstetrics and Gynecology, Duke University School of Medicine and Duke Global Health Institute, Duke University, Durham, USAc Clinical HIV Research Unit, Department of Medicine, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africad Right to Care, Johannesburg, South Africae Cytology Unit, Department of Anatomical Pathology, Faculty of Health Sciences, University of the Witwatersrand and National Health Laboratory Service, Johannesburg, South Africaf Lineberger Comprehensive Cancer Center, Chapel Hill, USA |
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| Abstract: | ObjectiveTo assess the effect of bacterial vaginosis (BV) on the risk of high-grade squamous intraepithelial lesions (HSIL) among HIV-seropositive women.MethodsA hospital-based prospective cohort study of HIV-seropositive women was conducted in Johannesburg, South Africa from January 2005 to September 2009. Multivariate log-binomial and Poisson regressions were used to estimate prevalence and rate ratios, respectively.ResultsAmong 1954 HIV-seropositive women, the baseline prevalence of HSIL was 17%. BV prevalence was high (54%) and showed no association with prevalence of HSIL (adjusted prevalence ratio, 1.12; 95% confidence intervals (CI), 0.92-1.35) nor with cervical lesion progression at follow-up visit (n = 503) (adjusted rate ratio: 1.00; 95% CI, 0.65-1.53).ConclusionAmong HIV-seropositive women, BV was not associated with an increased risk of HSIL or cervical lesion progression. |
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| Keywords: | Bacterial vaginosis Cervical lesions HIV |
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