系统性红斑狼疮患者血脂的变化及其临床意义

目的 探讨系统性红斑狼疮患者血脂的变化及其临床意义.方法 回顾性分析85例初诊未用激素治疗、56例已用激素治疗的系统性红斑狼疮患者和60例正常健康体检者的血脂变化.结果 已用激素治疗的系统性红斑狼疮患者甘油三酯、总胆固醇、低密度脂蛋白胆固醇与正常对照者和未用激素治疗的系统性红斑狼疮患者比较均明显增高（P＜0.05）;未用激素治疗的系统性红斑狼疮患者与正常对照者比较则无明显差异,但血脂异常患者占51.8%（44/85）,其中25例狼疮肾炎患者22例血脂异常,且与正常对照者比较有明显差异（P＜0.05）.结论 系统性红斑狼疮患者血脂异常主要与肾脏损害和大剂量激素使用有关,血脂检测对系统性红斑狼疮患者预防和治疗高血脂症所引起的各种并发症有一定的临床意义.

Changes and Significance of Blood Lipids in Patients with Systemic Lupus Erythematosus

Aim To investigate the changes and the clinical significances of blood lipids in patients with systemic lupus erythematosus(SLE).Methods Retrospective analysis was done on the changes of blood lipids in 85 SLE patients who hadn't been treated with steroid,56 SLE patients who had been treated with steroid and 60 healthy individials.Results The level of triglyceride(TG),total cholesterol(TC) and low density lipoprotein cholesterol(LDLC) were higher in SLE patients who had been treated with steroid than that of control and that of SLE patients who hadn't been treated with steroid(P<0.05),but had no significant difference between SLE patients who hadn't been treated with steroid and control(P>0.05).The level of blood lipids was abnormal in 51.8%(44/85) of the patients who hadn't been treated with steroid,and in 22/25 patients who had renal involvement.It had significant difference between SLE patients who had renal involvement and control(P<0.01).Conclusions The levels of blood lipids were abnormal in SLE patients.It is associated with renal involvement and high dose corticosteroids.The measurement of blood lipids is important for the patient with SLE to prevent and treat the complication of the disease of high blood lipids.