Transmission permeability of tuberculosis involving immigrants, revealed by a multicentre analysis of clusters |
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Authors: | N. Alonso Rodrí guez,F. Chaves,J. Iñ igo,E. Bouza,D. Garcí a de Viedma, the TB Molecular Epidemiology Study Group of Madrid S. André s,R. Cí as,R. Daza,D. Domingo,J. Esteban,J. Garcí a,E. Gó mez Mampaso,M. Herranz,E. Palenque, M. J. Ruiz Serrano |
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Affiliation: | Hospital General Universitario Gregorio Marañón;, CIBER Enfermedades Respiratorias (CIBERES);, Hospital Doce de Octubre;, Consejería de Sanidad;, Hospital Clínico San Carlos;, Hospital Puerta de Hierro;, Hospital de la Princesa;, Fundación Jiménez Díaz;, Hospital La Paz;and Hospital Ramón y Cajal, Madrid, Spain;in alphabetical order:;  |
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Abstract: | In recent years, the number of cases of tuberculosis (TB) among immigrants in Spain has increased markedly, and led to this analysis of the recent transmission patterns of TB in the immigrant population in Madrid. The countries from which the highest number of immigrant cases have been reported were Ecuador (21%), Romania (16%), Morocco (12%), Peru (11%) and Bolivia (9%). Fifty-one per cent of the cases were from South America. In a multicentre study (2004–2006), IS 6110 restriction fragment length polymorphism and spoligotyping were used to genotype the Mycobacterium tuberculosis isolates from 632 immigrant cases from 47 countries. A total of 183 cases (29%) were grouped into 59 clusters, which are markers of potential transmission events. Most of the clusters (81%) included patients living in different healthcare districts, and 54% of the clusters were multinational. When a sample of 478 autochthonous cases was included, 53% of the clusters involving immigrants also included autochthonous cases. This study revealed marked transmission permeability among nationalities and between the immigrant and the autochthonous populations. |
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Keywords: | Immigration molecular epidemiology transmission permeability tuberculosis |
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