Modulation of alpha 1-acid glycoprotein (AGP) gene induction following honey bee venom administration to adjuvant arthritic (AA) rats; possible role of AGP on AA development. |
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| Authors: | M Yiangou C Konidaris P Victoratos L Hadjipetrou-Kourounakis |
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| Affiliation: | Faculty of Sciences, School of Biology, Department of Genetics, Development and Molecular Biology, Aristotle University of Thessaloniki, Greece. |
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| Abstract: | Honey bee venom (HBV) administration to adjuvant arthritic (AA) rats resulted in a significant suppression of arthritis and in suppression of the hepatic acute phase alpha 1-acid glycoprotein (AGP) gene induction at the early stages of disease development. AGP administration in AA rats resulted in acceleration of arthritis development and in increase of severity and duration of the disease. IL-1, IL-6, tumour necrosis factor (TNF) and glucocorticoids alone are not responsible for the HBV-mediated AGP gene down-regulation. These results indicate that AGP gene expression in AA and HBV-treated AA rats involves the interaction of several factors, and that AGP plays a role for AA development in rats. |
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| Keywords: | honey been venom adjuvant arthritis α1-acid glycoprotein cytokines |
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