成人慢性特发性血小板减少性紫癜临床分析

目的：探讨血小板计数（Plt）、血小板平均体积（MPV）和血小板分布宽度（PDW）在成人慢性特发性血小板减少性紫癜（ITP）皮质激素疗效判定中的临床意义,以及初始骨髓巨核细胞总数与疗效关系。方法：分析35例治疗前后的d3、d5、d10的Plt、MPV和PDW变化,以及初始骨髓巨核细胞总数。结果：治疗后d3的Plt与治疗前比较无显著性差异（P〉0.05）,d5、d10与治疗前有显著性差异（P〈0.05）。而MPV、PDW在治疗后d3、d5、d10与治疗前比较,以及d5与d10比较差异均有显著性（P〈0.05）,初始骨髓巨核细胞总数增多患者疗效优于骨髓巨核细胞总数正常和减少患者（P〈0.05）。结论：MPV和PDW有助于诊断和早期疗效判定;初始骨髓巨核细胞数可作为慢性ITP疗效评价指标。

Clinical Analysis of Adult Chronic Idiopathic Thrombocytopenic Purpura

Objective: To investigate the blood platelet count (Plt), mean platelet volume (MPV) and platelet distribution width (PDW) in adults with chronic idiopathic thrombocytopenic purpura (ITP) to determine efficacy of corticosteroids in the clinical significance, as well as the total number of initial bone marrow megakaryocytes and affect relationship. Methods: Analysis of 35 cases before and after treatment d3、d5, d10’s Plt, MPV and PDW change, and the initial total number of bone marrow megakaryocytes. Results: After treatment, the Plt and treatment of pre-d3 was no significant difference (P> 0.05), d5、d10 and treatment before significant difference (P <0.05). The MPV, PDW after treatment d3、d5、d10 compared with those before treatment, and the difference between d5 and d10 were significantly (P <0.05), the initial increase in the total number of bone marrow megakaryocytes in patients with more effective than the total number of bone marrow megakaryocytes of normal and reduced in patients(P<0.05). Conclusion: MPV and PDW will help determine the diagnosis and early efficacy; the initial number of bone marrow megakaryocytes with chronic ITP can be used as indicators of efficacy evaluation.