| 灯盏花素结肠定位片的制备工艺及体外释放度评价 |
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| 引用本文： | 李艳玲,王锦玉,杨德斌,董美虹,仝燕. 灯盏花素结肠定位片的制备工艺及体外释放度评价[J]. 中国中药杂志, 2013, 38(6): 817-820 |
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| 作者姓名： | 李艳玲 王锦玉 杨德斌 董美虹 仝燕 |
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| 作者单位： | 1. 中国中医科学院中药研究所,北京100700;天津中医药大学,天津300193
2. 中国中医科学院中药研究所,北京,100700 |
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| 基金项目： | 国家"重大新药创制"科技重大专项(2009ZX09301-005) |
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| 摘 要： | 目的:拟制备中药新制剂pH依赖型灯盏花结肠定位片,并对其体外释放性能进行考察,探讨制备中药结肠靶向制剂的可行性.方法:以灯盏花中的有效成分灯盏花乙素为评价指标,对制剂的包衣处方进行筛选;采用体外释放度测定法考察该制剂的体外释放性能.结果:体外释放度测定结果表明,灯盏花乙素在pH l.2稀盐酸溶液2h中未检测到;在pH 6.8磷酸盐缓冲液中,4h累积溶出率均小于5％;而在pH7.6磷酸盐缓冲液中,lh累积溶出率均达90％以上.结论:制备得灯盏花素结肠定位片,该制剂能达到结肠定位释药的目的.
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| 关 键 词： | pH依赖型 灯盏花素结肠定位片 制备方法 体外释放度评价 |
| 收稿时间： | 2012-07-11 |
Evaluation on preparation process of brevisapin colon-specific tables and its in vitro release |
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| LI Yan-ling,WANG Jin-yu,YANG De-bin,DONG Mei-hong and TONG Yan. Evaluation on preparation process of brevisapin colon-specific tables and its in vitro release[J]. China Journal of Chinese Materia Medica, 2013, 38(6): 817-820 |
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| Authors: | LI Yan-ling WANG Jin-yu YANG De-bin DONG Mei-hong TONG Yan |
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| Affiliation: | Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China |
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| Abstract: | |
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| Keywords: | pH-dependent brevisapin colon-specific tablets preparation method evaluation on in vitro release |
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