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| 氯化镉对雄性生殖系统生理机能的影响 | |
| 引用本文： | 李建秀,王晓梅,杨曙民,王丽君. 氯化镉对雄性生殖系统生理机能的影响[J]. 中国公共卫生, 2003, 19(5): 566-567 |
| 作者姓名： | 李建秀 王晓梅 杨曙民 王丽君 |
| 作者单位： | 1. 邯郸医学高等专科学校生理教研室,邯郸市,056002 2. 河北建筑科技学院职工医院 3. 邯郸建工局医院 |
| 摘 要： | 目的 探讨氯化镉对雄性生殖系统生理机能的影响。方法 采用职业流行病学调查与动物实验相结合的方法分析镉作业男工精液中的微量元素；40只小鼠随机分为4组：氯化镉3．5，7．0，14、0mg／kg实验组和蒸馏水对照组，灌胃染毒。观察睾丸的病理组织学改变，测定睾丸细胞DNA含量和睾丸中微量元素含量。结果 接触组作业男工精液中镉含量明显高于对照组(P＜0．01)。实验组小鼠睾丸中铜含量增高(P＜0．05)。睾丸的超微结构出现改变，单倍体细胞DNA含量下降(P＜0．01)。结论 氯化镉可影响雄性生殖系统的生理机能，导致生育力下降。 |
| 关 键 词： | 氯化镉 镉作业男工 微量元素 睾丸细胞DNA含量 |
| 文章编号： | 1001-0580(2003)05-0566-02 |
| 修稿时间： | 2002-07-01 |
Effect of cadmium chloride on physiological function of male reproductive system |
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| LI Jian-xiu,WANG Xiao-mei,YANG Shu-min,et al.. Effect of cadmium chloride on physiological function of male reproductive system[J]. Chinese Journal of Public Health, 2003, 19(5): 566-567 | |
| Authors: | LI Jian-xiu WANG Xiao-mei YANG Shu-min et al. |
| Affiliation: | LI Jian-xiu,WANG Xiao-mei,YANG Shu-min,et al.Handan Medical College |
| Abstract: | Objective To study effect of cadmium chloride on physiological function of male reproductive system.Methods Microelement levels in semen were analysed for male workers exposed to cadmium.40 mice were divided into 4 groups:cadmium chloride 3.5,7.0,14.0?mg/kg experimental groups and the control group.They were administrated through the stomachs.The ultrastucture in testis,DNA level in testis cells,microelement levels in testis were observed with occupational epidemiologic investigation and animal experiment .Results Cadmium levels in semen of male workers exposed to cadmium were higher than the control group(P<0.01).Cadmium level in testis were higher (P<0.05).Ultrastucture in testis converted.DNA level of single cell was lower (P<0.01).Conclusion Cadmium chloride affected physiological function of male reproductive system,lowered genitality. |
| Keywords: | cadmium chloride male workers exposed to cadmium microelement DNA level in testis cells |
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