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Subjective and Objective Measures of Dryness Symptoms in Primary Sjögren's Syndrome: Capturing the Discrepancy |
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| Authors: | Oriana M. Bezzina Peter Gallagher Sheryl Mitchell Simon J. Bowman Bridget Griffiths Victoria Hindmarsh Ben Hargreaves Elizabeth J. Price Colin T. Pease Paul Emery Peter Lanyon Michele Bombardieri Nurhan Sutcliffe Costantino Pitzalis John Hunter Monica Gupta John McLaren Anne M. Cooper Marian Regan Ian P. Giles David A. Isenberg Vadivelu Saravanan David Coady Bhaskar Dasgupta Neil J. McHugh Steven A. Young‐Min Robert J. Moots Nagui Gendi Mohammed Akil Kirsten MacKay W. Fai Ng Lucy J. Robinson the UK Primary Sjögren's Syndrome Registry |
| Affiliation: | 1. Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK;2. Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK;3. University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK;4. Great Western Hospitals NHS Foundation Trust, Swindon, Wiltshire, UK;5. Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Chapel Allerton Hospital, NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals Trust, Leeds, UK;6. Nottingham University Hospitals NHS Trust, Nottingham, UK;7. Barts and the London NHS Trust and Barts and the London School of Medicine and Dentistry, London, UK;8. Barts Health, London, UK;9. Gartnavel General Hospital, Glasgow, Scotland;10. NHS Fife, Whyteman's Brae Hospital, Kirkcaldy;11. Royal Hampshire County Hospital, Winchester and Portsmouth Hospitals NHS Trust, Portsmouth, UK;12. Royal Derby Hospital, Derby, UK;13. University College London Hospitals NHS Foundation Trust, London, UK;14. Queen Elizabeth Hospital, Gateshead;15. Sunderland Royal Hospital, Sunderland, UK;16. Southend University Hospital, Southend, UK;17. Royal National Hospital for Rheumatic Diseases, Bath, UK;18. Portsmouth Hospitals NHS Trust, Portsmouth, UK;19. Aintree University Hospitals, Liverpool, UK;20. Basildon Hospital, Basildon, UK;21. Royal Hallamshire Hospital, Sheffield, UK;22. Torbay Hospital, Torquay, UK;23. Musculoskeletal Research Group, Institute of Cellular Medicine & Newcastle NIHR Biomedical Research Centre for Ageing and Chronic Diseases, Newcastle University, and Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK |
| Abstract: | ObjectiveTo develop a novel method for capturing the discrepancy between objective tests and subjective dryness symptoms (a sensitivity scale) and to explore predictors of dryness sensitivity.MethodsArchive data from the UK Primary Sjögren's Syndrome Registry (n = 688) were used. Patients were classified on a scale from ?5 (stoical) to +5 (sensitive) depending on the degree of discrepancy between their objective and subjective symptoms classes. Sensitivity scores were correlated with demographic variables, disease‐related factors, and symptoms of pain, fatigue, anxiety, and depression.ResultsPatients were on average relatively stoical for both types of dryness symptoms (mean ± SD ocular dryness ?0.42 ± 2.2 and ?1.24 ± 1.6 oral dryness). Twenty‐seven percent of patients were classified as sensitive to ocular dryness and 9% to oral dryness. Hierarchical regression analyses identified the strongest predictor of ocular dryness sensitivity to be self‐reported pain and that of oral dryness sensitivity to be self‐reported fatigue.ConclusionOcular and oral dryness sensitivity can be classified on a continuous scale. The 2 symptom types are predicted by different variables. A large number of factors remain to be explored that may impact symptom sensitivity in primary Sjögren?s syndrome, and the proposed method could be used to identify relatively sensitive and stoical patients for future studies. |
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