85例异位妊娠保守性治疗的临床分析

目的:探讨异位妊娠保守性治疗的临床应用价值。方法: 回顾性分析1997年1月~2003年12月住院确诊为异位妊娠并适合保守治疗的患者85例, 随机采用甲氨喋呤化疗44例, 米非司酮治疗41例。比较各组疗效、住院时间、住院费用、血清β-HCG下降情况及副反应。结果: 甲氨喋呤组治愈率为72. 73%, 米非司酮组治愈率为73. 17%; 甲氨喋呤组和米非司酮组的平均住院时间分别17 .86±3 .21d和5 .34±2 .68d, 住院费用分别为815±62 .35元和786±68. 54元; 甲氨喋呤组和米非司酮组血β-HCG下降的时间分别为HCG下降的时间为15 .98±7. 16d和14. 77±6. 89d; 甲氨喋呤及米非司酮的副反应发生率分别为50 .00%及24. 39%, 二者间有统计学差异, (P<0 .05 )。结论: 米非司酮治疗异位妊娠是一种有效、安全、方便的药物,且便于门诊应用; 在异位妊娠能够得到早期诊断的前提下, 其应用前景广阔, 有可能作为异位妊娠保守治疗的首选药物。

Clinical analysis of 85 cases of ectopic pregnancies with conservative treatment

Objective:To explore the clinical application value of conservative treatment in ectopic pregnancy. Methods:85 cases diagnosed as ectopic pregnancy with conservative treatment from Jan 1997 to Dec 2003 retrospectively analyzed were randomly divided into methotrexate (MTX) group (44 cases) and mifepristone group (41 cases). The therapeutic effect, duration, expense of hospitalization, decrease of serum human chorionic gonadotropin-β(β-HCG) and adverse effect were compared between two groups.Results:The curative rate in MTX group and mifepristone group was 72.73% and 73.17%, respectively. The average hospitalization duration was (17.86±3.21)d and (5.34±2.68)d, the expenses were (815±62.35)RMB and (786±68.54)RMB, the the time of serumβ-HCG level declined to normal was (15.98±7.16)days and (14.77±6.89)days of MTX and mifepristone group, respectively. There was significant difference (P<0.05) in incidence of adverse effect between MTX group (50.00%) and mifepristone (24.39%).Conclusion:Mifepristone should be a kind of effective, safe and convenient drug, which could be easily used in clinics and might be of choice in conservative treatment of ectopic pregnancy with precondition of ectopic pregnancy early diagnosed.