癣清双酶(DNA-2E)抗真菌药效学的实验研究

目的:研究癣清(DNA-2E)的抗真菌药效学作用。方法:采用浓度梯度法研究癣清(DNA-2E)对红色毛癣菌、须状毛癣菌的最低抑菌浓度(M IC)。结果:癣清(DNA-2E)对红色毛癣菌、须状毛癣菌的最低抑菌浓度(M IC)范围分别为0.0 625~0.125 mg/mL和0.03 125~0.125 mg/mL,两组比较差异无显著性;2%和4%癣清(DNA-2E)对豚鼠须状毛癣菌感染足癣、体癣有较好疗效,与1%足光粉比较差异无显著性,与蒸镏水组比较差异有高度显著性;4%和6%癣清(DNA-2E)止痒作用与1%足光粉相比差异无显著性,与蒸镏水组比较差异有高度显著性。结论:癣清(DNA-2E)外用具有较好的抗真菌及止痒作用。

Experimental study on pharmacodynamics of DNA-2E on fungi

Objective: To study the pharmacodynamics of DNA-2E on fungi.Methods: Concentration gradient method was used to detect the minimal inhibitory concentrations(MIC)of DNA-2E on trichophyton rubrum and beard-like trichophyton.Results: The ranges of MIC of DNA-2E on trichophyton rubrum and beard-like trichophyton were 0.0625～0.125mg/mL and 0.03125～0.125mg/mL respectively;of which there was no significant difference between the two fungi.Both 2% and 4% DNA-2E had better effects on ringworm of guinea pig in feet and body infected by beard-like trichophyton,which showed significant difference compared to distilled water and no significant difference compared to 1% Zuguang powder.Both 4% and 6% DNA-2E had better Antipruritic effect,which showed no significant difference compared to 2% Zuguang powder and significant difference compared to distilled water.Conclusion: DNA-2E has better effects on fungi(antimycotic) and Antipruritic by external use.