Expression of the L-type calcium channel in human heart failure |
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| Authors: | Joachim Hersel Simon Jung Paul Mohacsi and Roger Hullin |
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| Institution: | (1) Cardiology Division, Department of Medicine, Queen Mary Hospital, the University of Hong Kong, Hong Kong, China;(2) Research Center of Heart, Brain, Hormone and Healthy Aging, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong, China;(3) Eye Institute, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong, China; |
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| Abstract: | L-type calcium channels play an important role in excitation-contraction coupling. After cardiomyocyte depolarization L-type calcium channels open and Ca 2+ ions enter the cell. These small Ca 2+ inward currents trigger calcium release from the junctional sarcoplasmic reticulum, a process called calcium-induced calcium release. Subsequently, the cytosolic Ca 2+ concentration rises rapidly to levels that initiate contraction. In heart failure calcium-induced calcium release is disturbed, and in this review we focus on the L-type calcium channel and its contribution to this defective excitation-contraction coupling. |
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