Salicornia herbacea prevents high fat diet-induced hyperglycemia and hyperlipidemia in ICR mice |
| |
Authors: | Sang Hyun Park Sung Kwon Ko Jin Gyu Choi Sung Hyun Chung |
| |
Affiliation: | School of Pharmacy, Kyung Hee University, Seoul, Korea. |
| |
Abstract: | Salicornia herbacea L. (Chenopodiaceae) has been used as a seasoned vegetable by living in coastal areas. S. herbacea (SH) has been demonstrated to stimulate cytokine production, nitric oxide release, and to show anti-oxidative effect. In a series of investigations to develop potential anti-diabetic and/or anti-hyperlipidemic agents from Korean indigenous plants, 50% ethanol extract of Salicornia herbacea was found to prevent the onset of the hyperglycemia and hyperlipidemia induced by high fat diet in ICR mice. At 6 week old, the ICR mice were randomly divided into five groups; two control and three treatment groups. The control mice were to receive either a regular diet (RD) or high-fat diet (HFD), and the treatment groups were fed a high fat diet with either 350 mg/kg, 700 mg/kg of SH (SH350 and SH700) or 250 mg/kg of metformin (MT250) for a 10-week period. SH not only reduced body weight but also corrected associated hyperglycemia and hyperlipidemia in a dose dependent manner. SH exerted beneficial effects on the plasma glucose and lipid homeostasis possibly ascribed to its specific effects on lipogenesis related genes (SREBP1a, FAS, GAPT), and PEPCK, glucose 6-phosphatase gene expressions in liver. Ethanol extract of S. herbacea has potential as a preventive agent for type 2 diabetes (and possibly hyperlipidemia) and deserves future clinical trial. |
| |
Keywords: | Salicomia herbacea High fat diet Type 2 diabetes Lipogenesis related genes PEPCK Glucose 6-phosphatase |
本文献已被 PubMed SpringerLink 等数据库收录! |
|