大鼠基底前脑NGFR神经元出生后的发育

目的：研究基底前脑神经生长因子受体（ＮＧＦＲ）阳性神经元在出生后早期的发育变化。方法：６０只新生大鼠按出生后当天 Ｐ０、Ｐ１、Ｐ３、Ｐ５、Ｐ７、Ｐ９、Ｐ１１、Ｐ１３、Ｐ１５和 Ｐ３０天 １０个时间组进行灌注、固定和取材，每个时间组６ ．只动物，冰冻切片后进行ＮＧＦＲ的免疫组织化学染色。结果：基底前脑内侧隔核、斜角带核、腹侧苍白球及视前大细胞核从出生当天即有 ＮＧＦＲ阳性细胞出现，这些阳性细胞逐渐发育生长， ３０天时已基本成熟。结论：基底前脑 ＮＧＦＲ神经元在出生后早期的发育有一定的规律。

Development of NGFR Neurons in Postnatal Rat Basal Forebrain

Objective: To explore the developmental regularity of nerve growth factor receptor positive neurons in basal forebrain in postnatal rat. Method: 60 rats, aged from postnatal PO, P1,P3, P5, P7, P9, Pll, P13, P15 and P30 were used, 6 rats for each age group. The rats were perfused and post fixed, the brains were cut on a freezing microtome, the slides were subject to immunohistochemistry staining of NGFR. Results: NGFR positive neurons were detected on PO in the medial septum, diagonal band of broca, ventral pallidum and magnocellular preoptic area. NGFR positive neurons gradually grew and differentiated with the increasement of postnatal age. The NGFR neurons were basically matured on P30. Conclusion: There is certain regularity in the development of NGFR neurons in postnatal rat hasal forebrain.