从滋养血管成熟化探讨稳定动脉粥样硬化易损斑块的作用

动脉粥样硬化(As)疾病在各种易损因素的影响下,最终导致斑块的形成、破裂。在这一过程中斑块内新生血管的数量、通透性成为关键因素,因此,对于新生血管的调节成为近几年As疾病的治疗策略。然而,仅仅通过抑制新生血管的进展具有一定局限性,怎样促进斑块内滋养血管成熟化将成为稳定As易损斑块新的治疗途径。本文综述了滋养血管成熟化相关生长因子及信号通路,以期为As易损斑块新的治疗奠定理论基础。

Study on the role of vasa vasorum maturation in stabilizing vulnerable plaque of atherosclerosis

Atherosclerosis (As) disease, under the influence of various vulnerable factors, eventually leads to the formation and rupture of plaques. In this process, the quantity and permeability of plaque neovascularization are the key factors. Therefore, the regulation of angiogenesis has become a therapeutic strategy for As disease in recent years. However, there are some limitations only by inhibiting the development of new blood vessels, and how to promote the maturation of vasa vasorum in the plaque will become a new way to stabilize the vulnerable plaque of As. In this paper, we review the growth factors and signaling pathways related to the maturation of vasa vasorum, in order to lay a theoretical foundation for the new treatment of vulnerable plaque in As.