| 冠心病患者血清前蛋白转化酶枯草溶菌素9与小而密低密度脂蛋白胆固醇的相关性研究 |
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| 引用本文： | 韩耀霞,张强,边云飞,张娜娜,梁斌,白瑞,肖传实. 冠心病患者血清前蛋白转化酶枯草溶菌素9与小而密低密度脂蛋白胆固醇的相关性研究[J]. 中国动脉硬化杂志, 2017, 25(4): 383-386 |
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| 作者姓名： | 韩耀霞 张强 边云飞 张娜娜 梁斌 白瑞 肖传实 |
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| 作者单位： | 第一临床医学院心内科,,第一临床医学院心内科,,第二临床医学院心内科 山西省临床心血管药理实验室, 山西省太原市 030001,第一临床医学院心内科,,第二临床医学院心内科 山西省临床心血管药理实验室, 山西省太原市 030001,第二临床医学院心内科 山西省临床心血管药理实验室, 山西省太原市 030001,第一临床医学院心内科, |
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| 摘 要： | 目的探讨冠心病患者血清前蛋白转化酶枯草溶菌素9(PCSK9)与小而密低密度脂蛋白胆固醇(sd LDLC)的关系。方法收集2014年3月至2014年12月在山西医科大学第一医院住院且行冠状动脉造影术确诊为冠心病的患者100例作为冠心病组,同期健康体检者67例作为对照组。Lipoprint脂蛋白分析仪检测LDLC颗粒大小、sd LDLC颗粒数及sd LDLC所占LDLC的百分比(简称sd LDLC百分比);酶联免疫吸附法测定血清PCSK9。结果冠心病组LDLC颗粒大小低于对照组(264.07±6.78比267.37±5.15,P0.01),sd LDLC颗粒数多于对照组(5.0±9.5比4.0±5.0,P0.05),sd LDLC百分比大于对照组(5.95%±10.50%比3.70%±5.85%,P0.01)。冠心病组血清PCSK9显著高于对照组(15.48μg/L比14.95μg/L,U=-2.74,P=0.006)。冠心病组血清PCSK9与sd LDLC百分比、LDLC呈正相关(r=0.212,P=0.034;r=0.202,P=0.032)。结论冠心病患者血清PCSK9与sd LDLC百分比呈正相关,抑制PCSK9可以预防冠心病。
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| 关 键 词： | 冠心病 前蛋白转化酶枯草溶菌素9 小而密低密度脂蛋白胆固醇 |
| 收稿时间： | 2015-05-07 |
| 修稿时间： | 2016-08-30 |
Study on the correlation between serum proprotein convertase subtilisin/kexin type 9 and small and dense low density lipoprotein cholesterol in patients with coronary artery disease |
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| HAN Yao-Xi,ZHANG Qiang,BIAN Yun-Fei,ZHANG Na-N,LIANG Bin,BAI Rui and XIAO Chuan-Shi. Study on the correlation between serum proprotein convertase subtilisin/kexin type 9 and small and dense low density lipoprotein cholesterol in patients with coronary artery disease[J]. Chinese Journal of Arteriosclerosis, 2017, 25(4): 383-386 |
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| Authors: | HAN Yao-Xi ZHANG Qiang BIAN Yun-Fei ZHANG Na-N LIANG Bin BAI Rui XIAO Chuan-Shi |
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| Affiliation: | Department of Cardiology, First Affiliated Hospital,,Department of Cardiology, First Affiliated Hospital,,Department of Cardiology, Second Affiliated Hospital & Clinical Cardiovascular Pharmacology Laboratory of Shanxi Province, Shanxi Medical University, Taiyuan, Shanxi 030001, China,Department of Cardiology, First Affiliated Hospital,,Department of Cardiology, Second Affiliated Hospital & Clinical Cardiovascular Pharmacology Laboratory of Shanxi Province, Shanxi Medical University, Taiyuan, Shanxi 030001, China,Department of Cardiology, Second Affiliated Hospital & Clinical Cardiovascular Pharmacology Laboratory of Shanxi Province, Shanxi Medical University, Taiyuan, Shanxi 030001, China and Department of Cardiology, First Affiliated Hospital, |
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| Abstract: | |
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| Keywords: | Coronary heart disease Proprotein convertase subtilisin/kexin type 9 Small and dense low density lipoprotein cholesterol |
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