| 线粒体功能障碍与高血压 |
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| 引用本文： | 杨建,高莹,史慧妍,刘彬. 线粒体功能障碍与高血压[J]. 中国动脉硬化杂志, 2017, 25(10): 1061-1066 |
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| 作者姓名： | 杨建 高莹 史慧妍 刘彬 |
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| 作者单位： | 天津中医药大学第一附属医院 天津市针灸学重点实验室, 天津市 300193,天津中医药大学第一附属医院 天津市针灸学重点实验室, 天津市 300193,天津中医药大学第一附属医院 天津市针灸学重点实验室, 天津市 300193,天津中医药大学第一附属医院 天津市针灸学重点实验室, 天津市 300193 |
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| 基金项目： | 国家自然科学基金青年科学基金项目(81503635) |
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| 摘 要： | 高血压发病率在全球范围内呈逐年上升趋势,全面深入研究高血压发病机制已成为医学界共识。与线粒体功能障碍有关的供能不足、氧化损伤、信号传导异常和线粒体基因突变是高血压产生的危险因素。了解线粒体功能损伤与高血压的关系将为高血压的研究和治疗提供新的思路。本文从线粒体功能、线粒体功能障碍以及线粒体功能障碍与高血压的关系三个角度做详细阐述。
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| 关 键 词： | 线粒体 高血压 线粒体功能障碍 |
| 收稿时间： | 2016-12-26 |
| 修稿时间： | 2017-02-18 |
Mitochondrial dysfunction and hypertension |
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| YANG Jian,GAO Ying,SHI Hui-Yan and LIU Bin. Mitochondrial dysfunction and hypertension[J]. Chinese Journal of Arteriosclerosis, 2017, 25(10): 1061-1066 |
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| Authors: | YANG Jian GAO Ying SHI Hui-Yan LIU Bin |
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| Affiliation: | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine & Key Laboratory of Acupuncture in Tianjin, Tianjin 300193, China,First Teaching Hospital of Tianjin University of Traditional Chinese Medicine & Key Laboratory of Acupuncture in Tianjin, Tianjin 300193, China,First Teaching Hospital of Tianjin University of Traditional Chinese Medicine & Key Laboratory of Acupuncture in Tianjin, Tianjin 300193, China and First Teaching Hospital of Tianjin University of Traditional Chinese Medicine & Key Laboratory of Acupuncture in Tianjin, Tianjin 300193, China |
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| Abstract: | The incidence of hypertension is increasing year by year in the whole world. It has become the consensus of the medical community to study the pathogenesis of hypertension. The insufficiency of energy supply, oxidative damage and abnormal signal transduction caused by mitochondrial dysfunction and mitochondrial gene mutation are the risk factors of hypertension. Understanding the relationship between mitochondrial dysfunction and hypertension will provide new ideas for the research and treatment of hypertension. This paper has discussed mitochondrial function, mitochondrial dysfunction and the relationship between mitochondrial dysfunction and hypertension in great detail. |
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| Keywords: | Mitochondria Hypertension Mitochondrial dysfunction |
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