骨保护素与动脉粥样硬化的研究进展

骨保护素是属于肿瘤坏死因子超家族成员之一的一种可溶性糖蛋白,近来研究表明骨保护素不仅参与骨代谢,同时与体内能量和糖脂代谢关系密切,且其与动脉粥样硬化及糖脂代谢异常相关的心血管病变、微血管病变联系紧密。骨保护素可能通过调节糖脂代谢和内皮功能、抑制血管钙化、抑制炎症、抑制凋亡等机制参与动脉粥样硬化发生发展过程。

Research progress of osteoprotegerin and atherosclerosis

A soluble glycoprotein, termed osteoprotegerin, is a novel member of the tumor necrosis factor receptor superfamily. Recent studies have shown that osteoprotegerin is not only involved in bone metabolism, but also closely related to energy metabolism in vivo, glycolipid metabolism. And it is closely related to atherosclerosis and glycolipid metabolism disorders, cardiovascular and microvascular diseases. It is not clear that the mechanism is involved in the occurrence and progression of atherosclerosis by regulating glucose and lipid metabolism, endothelial function, inhibiting vascular calcification, inhibiting inflammation, inhibiting apoptosis and so on.