Alpha-fetoprotein-producing transitional cell carcinoma of the urinary bladder: a case report |
| |
| Authors: | Chang-Hsien Lu Wen-Chi Chou Yu-Shin Hung Kun-Yun Yeh Swei Sheu Chuang-Chi Liaw |
| |
| Institution: | (1) Division of Hematology/Oncology, Department of Internal Medicine, Gang Gung Memorial Hospital, Jiayi, Taiwan;(2) Division of Oncology, Department of Internal Medicine, Saint Paul’s Hospital, Taoyuan, Taiwan;(3) Division of Hematology/Oncology, Department of Internal Medicine, Chang Gung University College of Medicine, Chang-Gung Memorial Hospital, 199 Tung Hwa North Road, Taipei, 105, Taiwan;(4) Division of Hematology/Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Keelung, Taiwan;(5) Department of Pathology, Chang Gung University College of Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan; |
| |
| Abstract: | We report a 76-year-old man with alpha-fetoprotein (AFP)-producing transitional cell carcinoma of the bladder. Although the
serum level of AFP was 1,428 ng/ml, and he was anti-hepatitis C virus (anti-HCV) antibody-positive, liver tumors were not
detected by either a computed tomography (CT) scan or a hepatic angiography. However, removal of a bladder tumor by transurethral
resection and subsequent pathological examination revealed a grade III transitional cell carcinoma (TCC). Furthermore, immunohistochemical
detection of AFP was diffuse-positive. After the tumor partially responded to concomitant chemoradiotherapy, the serum AFP
levels decreased to 966 ng/ml. However, the tumor eventually progressed with multiple lung metastases, and serum AFP levels
increased to 3,906 ng/ml. In conclusion, AFP-producing TCC of urinary bladder is rare, and the nature and pathophysiology
remains unclear and warrants further investigation. |
| |
| Keywords: | Alpha-fetoprotein Transitional cell carcinoma Urinary bladder |
| 本文献已被 PubMed SpringerLink 等数据库收录！ |
|
